Document Detail

Nesfatin-1--role as possible new potent regulator of food intake.
MedLine Citation:
PMID:  20580651     Owner:  NLM     Status:  MEDLINE    
Nesfatin-1 is an 82 amino acid peptide recently discovered in the brain which is derived from nucleobindin2 (NUCB2), a protein that is highly conserved across mammalian species. Nesfatin-1 has received much attention over the past two years due to its reproducible food intake-reducing effect that is linked with recruitment of other hypothalamic peptides regulating feeding behavior. A growing amount of evidence also supports that various stressors activate fore- and hindbrain NUCB2/nesfatin-1 circuitries. In this review, we outline the central nervous system distribution of NUCB2/nesfatin-1, and recent developments on the peripheral expression of NUCB2/nesfatin-1, in particular its co-localization with ghrelin in gastric X/A-like cells and insulin in ss-cells of the endocrine pancreas. Functional studies related to the characteristics of nesfatin-1's inhibitory effects on dark phase food intake are detailed as well as the central activation of NUCB2/nesfatin-1 immunopositive neurons in the response to psychological, immune and visceral stressors. Lastly, potential clinical implications of targeting NUCB2/nesfatin-1 signaling and existing gaps in knowledge to ascertain the role and mechanisms of action of nesfatin-1 are presented.
Andreas Stengel; Yvette Taché
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2010-05-16
Journal Detail:
Title:  Regulatory peptides     Volume:  163     ISSN:  1873-1686     ISO Abbreviation:  Regul. Pept.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2011-01-26     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  18-23     Citation Subset:  IM    
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MeSH Terms
Central Nervous System / metabolism
Neurons / metabolism
Peptide Hormones / genetics,  metabolism*
Grant Support
33061//PHS HHS; DK-41301/DK/NIDDK NIH HHS; P30 DK041301/DK/NIDDK NIH HHS; P30 DK041301-20S19006/DK/NIDDK NIH HHS; R01 DK033061/DK/NIDDK NIH HHS; R01 DK033061-24/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Peptide Hormones

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