| Nesfatin-1--role as possible new potent regulator of food intake. | |
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MedLine Citation:
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PMID: 20580651 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nesfatin-1 is an 82 amino acid peptide recently discovered in the brain which is derived from nucleobindin2 (NUCB2), a protein that is highly conserved across mammalian species. Nesfatin-1 has received much attention over the past two years due to its reproducible food intake-reducing effect that is linked with recruitment of other hypothalamic peptides regulating feeding behavior. A growing amount of evidence also supports that various stressors activate fore- and hindbrain NUCB2/nesfatin-1 circuitries. In this review, we outline the central nervous system distribution of NUCB2/nesfatin-1, and recent developments on the peripheral expression of NUCB2/nesfatin-1, in particular its co-localization with ghrelin in gastric X/A-like cells and insulin in ss-cells of the endocrine pancreas. Functional studies related to the characteristics of nesfatin-1's inhibitory effects on dark phase food intake are detailed as well as the central activation of NUCB2/nesfatin-1 immunopositive neurons in the response to psychological, immune and visceral stressors. Lastly, potential clinical implications of targeting NUCB2/nesfatin-1 signaling and existing gaps in knowledge to ascertain the role and mechanisms of action of nesfatin-1 are presented. |
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Authors:
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Andreas Stengel; Yvette Taché |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2010-05-16 |
Journal Detail:
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Title: Regulatory peptides Volume: 163 ISSN: 1873-1686 ISO Abbreviation: Regul. Pept. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2011-01-26 Revised Date: 2011-08-10 |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: Netherlands |
Other Details:
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Languages: eng Pagination: 18-23 Citation Subset: IM |
Affiliation:
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Department of Medicine, CURE Digestive Diseases Research Center, Digestive Diseases Division UCLA, Los Angeles, CA 90073, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Central Nervous System / metabolism Eating* Humans Neurons / metabolism Peptide Hormones / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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33061//PHS HHS; DK-41301/DK/NIDDK NIH HHS; P30 DK041301-20S19006/DK/NIDDK NIH HHS; R01 DK033061-24/DK/NIDDK NIH HHS; R01 DK033061-26/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptide Hormones |
| Comments/Corrections | |
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