Document Detail


Nesfatin-1: a novel inhibitory regulator of food intake and body weight.
MedLine Citation:
PMID:  20546141     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The protein nucleobindin 2 (NUCB2) or NEFA (DNA binding/EF-hand/acidic amino acid rich region) was identified over a decade ago and implicated in intracellular processes. New developments came with the report that post-translational processing of hypothalamic NUCB2 may result in nesfatin-1, nesfatin-2 and nesfatin-3 and convergent studies showing that nesfatin-1 and full length NUCB2 injected in the brain potently inhibit the dark phase food intake in rodents including leptin receptor deficient Zucker rats. Nesfatin-1 also reduces body weight gain, suggesting a role as a new anorexigenic factor and modulator of energy balance. In light of the obesity epidemic and its associated diseases, underlying new mechanisms regulating food intake may be promising targets in the drug treatment of obese patients particularly as the vast majority of them display reduced leptin sensitivity or leptin resistance while nesfatin-1's mechanism of action is leptin independent. Although much progress on the localization of NUCB2/nesfatin-1 in the brain and periphery as well as on the understanding of nesfatin-1's anorexic effect have been achieved during the past three years, several important mechanisms have yet to be unraveled such as the identification of the nesfatin-1 receptor and the regulation of NUCB2 processing and nesfatin-1 release.
Authors:
A Stengel; M Goebel; Y Taché
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Obesity reviews : an official journal of the International Association for the Study of Obesity     Volume:  12     ISSN:  1467-789X     ISO Abbreviation:  Obes Rev     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-05-12     Revised Date:  2014-07-03    
Medline Journal Info:
Nlm Unique ID:  100897395     Medline TA:  Obes Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-71     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. obesity reviews © 2010 International Association for the Study of Obesity.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Regulation / drug effects*,  physiology
Body Weight / drug effects,  physiology
Calcium-Binding Proteins
DNA-Binding Proteins
Disease Models, Animal
Eating
Energy Intake / drug effects*,  physiology
Humans
Hypothalamus / drug effects*,  metabolism,  physiology
Leptin / metabolism
Nerve Tissue Proteins
Obesity / drug therapy,  metabolism
Peptide Hormones / metabolism,  physiology*
Rats
Satiety Response / drug effects*,  physiology
Signal Transduction
Grant Support
ID/Acronym/Agency:
DK-41301/DK/NIDDK NIH HHS; P30 DK041301/DK/NIDDK NIH HHS; R01 DK033061/DK/NIDDK NIH HHS; R01 DK033061-26/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/DNA-Binding Proteins; 0/Leptin; 0/Nerve Tissue Proteins; 0/Peptide Hormones; 0/nucleobindin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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