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Nesfatin-1 increases energy expenditure and reduces food intake in rats.
MedLine Citation:
PMID:  24596169     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: Energy homeostasis results from a balance of food intake and energy expenditure, accomplished by the interaction of peripheral and central nervous signals. The recently discovered adipokine nesfatin-1 is involved in the central control of food intake, but whether it also participates in the regulation of thermogenesis is unknown. Design and Methods: We administered nesfatin-1 intracerebroventricularly to freely moving, male Wistar rats and performed direct calorimetry to assess its effects on thermogenesis. Furthermore, we measured food intake and determined hypothalamic and N. tractus solitarius neuropeptide expression by quantitative real-time PCR. Leptin, which is involved in both the regulation of food intake and thermogenesis, was used as positive control. Results: We could for the first time show that central nervous administration of nesfatin-1 profoundly increases thermogenesis in rats to a similar extent as leptin and confirmed the role of both peptides in the control of food intake. Nesfatin-1 significantly downregulated neuropeptide Y mRNA expression in both hypothalamus and N. tractus solitarius. Conclusions: The results of our strongly support the prominent role of nesfatin-1 for both food intake and energy expenditure and neuropeptide Y neurons appear to be involved in this effect.
Authors:
Kerstin Wernecke; Ingolf Lamprecht; Olaf Jöhren; Hendrik Lehnert; Carla Schulz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-5
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 The Obesity Society.
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