Document Detail

Nervous system involvement in systemic lupus erythematosus, Sj?gren syndrome and scleroderma.
MedLine Citation:
PMID:  8256578     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The purpose of this study was to determine, whether there are any differences in the occurrence of nervous system involvement in different systemic rheumatic diseases. The further aim of the present study was to identify and distinguish primary involvement of the nervous system by these diseases and involvement that may be secondary to confounding factors. MATERIAL AND METHODS: The patient population consisted of 122 patients with a connective tissue disease (42 with systemic lupus erythematosus (SLE), 48 with Sj?gren's syndrome and 32 with scleroderma). The methods included neurological examination and standard electrophysiological tests. RESULTS: At least one neurological defect was diagnosed in 69% of SLE patients, in 71% of Sj?gren's syndrome patients and in 66% of scleroderma patients. Secondary factors might have contributed to the pathogenesis of neurological symptoms and signs in up to 25-34% of events. CONCLUSION: No significant differences were noted in the occurrence of neurological events in patients with SLE, Sj?gren's syndrome and scleroderma. The necessity to differentiate between neurological phenomena directly attributed to the systemic rheumatic disease and those which are totally unrelated or secondary events resulting indirectly from involvement of other organ systems is emphasized.
A Hietaharju; V J?ntti; M Korpela; H Frey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  88     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-13     Completed Date:  1994-01-13     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  299-308     Citation Subset:  IM    
Department of Clinical Sciences, University of Tampere, Finland.
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MeSH Terms
Brain / physiopathology
Diagnosis, Differential
Evoked Potentials, Visual
Lupus Erythematosus, Systemic / diagnosis,  immunology,  physiopathology*
Middle Aged
Nervous System / physiopathology*
Neurologic Examination
Prospective Studies
Scleroderma, Systemic / diagnosis,  immunology,  physiopathology*
Sjogren's Syndrome / diagnosis,  immunology,  physiopathology*

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