Document Detail


Nervous network for lower urinary tract function.
MedLine Citation:
PMID:  23088378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Traditionally, sensory signaling in the urinary bladder has been largely attributed to direct activation of bladder afferents. There is substantive evidence that sensory systems can be influenced by non-neuronal cells, such as the urothelium, which are able to respond to various types of stimuli that can include physiological, psychological and disease-related factors. The corresponding release of chemical mediators (through activation of a number of receptors/ion channels) can initiate signaling mechanisms between and within urothelial cells, as well as other cell types within the bladder wall including bladder nerves. However, the mechanisms underlying how various cell types in the bladder wall respond to normal filling and emptying, and are challenged by a variety of stressors (physical and chemical) are still not well understood. Alterations or defects in signaling mechanisms are likely to contribute to the pathophysiology of bladder disease with symptoms including urinary urgency, increased voiding frequency and pain. This review will discuss some of the components involved in control of lower urinary tract function, with an emphasis on the sensor and transducer roles of the urothelium.
Authors:
Lori A Birder
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-10-23
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  20     ISSN:  1442-2042     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-07-02     Revised Date:  2014-05-29    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  4-12     Citation Subset:  IM    
Copyright Information:
© 2012 The Japanese Urological Association.
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MeSH Terms
Descriptor/Qualifier:
Afferent Pathways
Animals
Cell Communication
Humans
Urethra / innervation*,  physiology
Urinary Bladder / innervation*,  physiology
Urothelium / physiology
Grant Support
ID/Acronym/Agency:
R01 DK057284/DK/NIDDK NIH HHS; R01 DK57284/DK/NIDDK NIH HHS; R37 DK054824/DK/NIDDK NIH HHS; R37 DK54824/DK/NIDDK NIH HHS
Comments/Corrections

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