Document Detail


Nerve terminals extend into the temporomandibular joint of adjuvant arthritic rats.
MedLine Citation:
PMID:  14575662     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The innervation of the temporomandibular joint (TMJ) has attracted particular interest because of the close association with complex mandibular movement. Although the pathological changes of disk innervation may have a crucial role in the development of TMJ pain, the innervation of the TMJ disk by experimentally induced arthritis has rarely been examined in detail. Arthritic rats were induced by injection with 0.1ml solution of Complete Freund's adjuvant (CFA). We investigated three-dimensional distribution of nerve fibers in the TMJ disk using immunohistochemistry for protein gene product-9.5 (PGP-9.5) and calcitonin gene-related peptide (CGRP) in naive and arthritic rats. To clarify the possible role of nerve growth factor (NGF) and its receptor on changes in peripheral innervation of the TMJ, the expressions of trkA and p75 receptor in trigeminal ganglia were examined. Although PGP-9.5 and CGRP immunoreactive (ir) fibers were seen in the peripheral part of the TMJ disk, they were not seen in its central part. The total length and the length density of PGP-9.5 ir and CGRP ir nerve fibers increased in arthritic rats. The innervation area of fibers proliferating in the rostro-medial part merged with that of fibers in the rostro-lateral part in the arthritic rats. In addition, the ratio of trkA- and p75-positive small- and medium-sized cells increased in trigeminal ganglia. It is assumed that increasing innervation of the TMJ disk may be important for the pathophysiology of TMJ pain. NGF and its receptors are likely involved in pathological changes of the TMJ disk.
Authors:
Masamichi Shinoda; Takashi Honda; Noriyuki Ozaki; Hisashi Hattori; Hideki Mizutani; Minoru Ueda; Yasuo Sugiura
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pain (London, England)     Volume:  7     ISSN:  1090-3801     ISO Abbreviation:  Eur J Pain     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-24     Completed Date:  2004-02-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9801774     Medline TA:  Eur J Pain     Country:  England    
Other Details:
Languages:  eng     Pagination:  493-505     Citation Subset:  IM    
Affiliation:
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arthritis / chemically induced,  metabolism*
Calcitonin Gene-Related Peptide / metabolism*
Carrier Proteins / metabolism
Freund's Adjuvant
Immunohistochemistry
Male
Membrane Proteins / metabolism
Nerve Fibers / chemistry,  metabolism*
Nerve Growth Factor / metabolism
Pain / metabolism
Rats
Rats, Inbred Lew
Receptor, Nerve Growth Factor
Receptor, trkA*
Receptors, Nerve Growth Factor / metabolism
Temporomandibular Joint / innervation*,  metabolism
Trigeminal Ganglion / metabolism
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Membrane Proteins; 0/Receptor, Nerve Growth Factor; 0/Receptors, Nerve Growth Factor; 83652-28-2/Calcitonin Gene-Related Peptide; 9007-81-2/Freund's Adjuvant; 9061-61-4/Nerve Growth Factor; EC 2.7.10.1/Receptor, trkA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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