Document Detail

Nerve outgrowth, synaptogenesis and bioelectric activity in fetal rat cerebral cortex tissue cultured in serum-free, chemically defined medium.
MedLine Citation:
PMID:  6272949     Owner:  NLM     Status:  MEDLINE    
Dissociated and non-dissociated cerebral cortex of fetal rat was successfully cultured in a serum-free, chemically defined medium for at least 18 days without any preincubation in serum-supplemented medium. Neurite outgrowth, synapse formation and spontaneous bioelectric activity, in its qualitative and quantitative aspects, were essentially the same as was observed in medium containing 20% heat-inactivated horse serum.
H J Romijn; A M Habets; M T Mud; P S Wolters
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  254     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  583-9     Citation Subset:  IM    
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MeSH Terms
Blood Proteins
Cell Differentiation*
Cells, Cultured
Cerebral Cortex / cytology*
Culture Media
Membrane Potentials
Microscopy, Electron
Rats, Inbred Strains
Synapses / ultrastructure*
Synaptic Transmission*
Reg. No./Substance:
0/Blood Proteins; 0/Culture Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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