Document Detail

Nerve injury alters the effects of interleukin-6 on nociceptive transmission in peripheral afferents.
MedLine Citation:
PMID:  14744602     Owner:  NLM     Status:  MEDLINE    
Interleukin-6 (IL-6) is markedly upregulated in the peripheral and central nervous systems following nerve injury; however, the functional effects of this are unclear. This study investigates the effect of peripheral interleukin-6 on nociceptive transmission in naive and neuropathic states. Using an in vitro rat skin-nerve preparation, 50 ng interleukin-6 inhibited responses of single nociceptive fibers to noxious heat. A 20-ng sample of interleukin-6 only inhibited heat responses in the presence of soluble interleukin-6 receptors. To examine in vivo effects of peripheral interleukin-6, extracellular recordings from dorsal horn neurons were made in anaesthetised naive, sham-operated and neuropathic (spinal nerve ligated) rats. Peripheral interleukin-6 (40-100 ng) markedly inhibited all naturally evoked neuronal responses in naive rats, yet only neuronal responses to heat in neuropathic rats. Behaviourally, intraplantar administration of interleukin-6 (0.01-1 microg) elicited ipsilateral thermal hypoalgesia in naive rats. Thus, interleukin-6 inhibits normal peripheral nociceptive transmission, yet such anti-nociceptive effects are attenuated following nerve injury in a modality-specific manner.
Sarah J L Flatters; Alyson J Fox; Anthony H Dickenson
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  484     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-27     Completed Date:  2004-09-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  183-91     Citation Subset:  IM    
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
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MeSH Terms
Action Potentials / drug effects*,  physiology
Afferent Pathways / drug effects,  injuries,  physiology
Hot Temperature / adverse effects
Interleukin-6 / pharmacology*
Pain Measurement / drug effects*,  methods
Peripheral Nerves / drug effects,  injuries,  physiology
Rats, Sprague-Dawley
Spinal Nerves / drug effects*,  injuries,  physiopathology*
Synaptic Transmission / drug effects,  physiology
Reg. No./Substance:

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