Document Detail

Nerve growth factor synthesis by mouse submandibular gland cells in culture.
MedLine Citation:
PMID:  8242346     Owner:  NLM     Status:  MEDLINE    
Mouse submandibular gland (SMG) cells in culture rarely retain functional properties of SMG cells in vivo. We demonstrate that both primary SMG cells and the mouse SMG cell line SCA-9 secrete biologically active nerve growth factor (NGF). However, primary cells secrete 40-fold more NGF than SCA-9 cells, demonstrating that SCA-9 cells cannot substitute for primary SMG cells for the study of SMG NGF in vitro.
M Fahnestock; Q Lu
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  621     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-23     Completed Date:  1993-12-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  339-42     Citation Subset:  IM    
Department of Biomedical Sciences, McMaster University, Hamilton, Ont., Canada.
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MeSH Terms
Cells, Cultured
Nerve Growth Factors / biosynthesis*
Submandibular Gland / cytology,  metabolism*
Grant Support
Reg. No./Substance:
0/Nerve Growth Factors
Erratum In:
Brain Res 1993 Nov 19;628(1-2):356

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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