Document Detail

Nerve growth factor chromatin receptor and cell surface receptor-regulated growth of melanocytes and nevus cells.
MedLine Citation:
PMID:  1279947     Owner:  NLM     Status:  MEDLINE    
RNA synthesis in melanocytes and nevus cells, and the proliferation of those cells in the presence of nerve growth factor (NGF) and 12-0-tetradecanoyl-phorbol-13-acetate (TPA), were found to correlate with the amount of NGF bound to the chromatin versus the total internalized NGF (n/c NGF = nuclear/cellular ration). In nevus cells and in melanocytes of the early passages (n/c NGF = 0.16-0.18), NGF slightly activated RNA synthesis but was without any effect on cell growth. At passage 5-6 of melanocytes (n/c NGF = 0.88), NGF inhibited RNA synthesis, which led to inhibition of cell growth. Removal of TPA from the culture of nevus cells resulted in increased n/c NGF ratio and in a switch from activatory to inhibitory action of NGF. The possibility that the cell surface receptor mediated the stimulatory effect of NGF and may antagonize the chromatin receptor-mediated inhibitory effect of NGF of melanocyte and nevus cell growth is discussed.
E M Rakowicz-Szulczynska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biological regulators and homeostatic agents     Volume:  6     ISSN:  0393-974X     ISO Abbreviation:  J. Biol. Regul. Homeost. Agents     Publication Date:    1992 Jan-Mar
Date Detail:
Created Date:  1992-12-02     Completed Date:  1992-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809253     Medline TA:  J Biol Regul Homeost Agents     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania.
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MeSH Terms
Cell Division / drug effects
Cell Membrane / metabolism
Cells, Cultured
Chromatin / metabolism
Melanocytes / cytology,  drug effects*,  metabolism
Nerve Growth Factors / metabolism,  pharmacology*
Nevus / metabolism,  pathology*
RNA / biosynthesis
Receptors, Nerve Growth Factor / metabolism*
Tetradecanoylphorbol Acetate / pharmacology
Reg. No./Substance:
0/Chromatin; 0/Nerve Growth Factors; 0/Receptors, Nerve Growth Factor; 16561-29-8/Tetradecanoylphorbol Acetate; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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