Document Detail

Nerve growth factor abrogates the tumorigenicity of human small cell lung cancer cell lines.
MedLine Citation:
PMID:  9560282     Owner:  NLM     Status:  MEDLINE    
Nerve growth factor (NGF) has antiproliferative and differentiating effects on adenomas of neuroendocrine origin. Cell lines derived from small-cell lung carcinoma (SCLC), a very aggressive neuroendocrine tumor, express NGF receptors. The role of NGF in the control of proliferation and progression of this carcinoma, however, has never been investigated. Chronic exposure of NCI-N-592 and GLC8 SCLC cell lines to NGF remarkably inhibited their proliferation rate both in vitro and in vivo, prevented their anchorage-independent clonal growth in soft agar, impaired their invasive capacity in vitro, and abolished their tumorigenic potential in nude mice. The proliferative response of SCLC cell lines to nicotine was also remarkably impaired by in vitro NGF treatment. Furthermore, NGF treatment activates in SCLC cell lines the expression and secretion of NGF. NGF thus reverts SCLC cell lines to a noninvasive, nontumorigenic phenotype that does not respond to nicotine and produces NGF.
C Missale; A Codignola; S Sigala; A Finardi; M Paez-Pereda; E Sher; P F Spano
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  95     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-04     Completed Date:  1998-06-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5366-71     Citation Subset:  IM    
Department of Biomedical Sciences and Biotechnology, Division of Pharmacology, University of Brescia, Via Valsabbina 19, 25124, Brescia, Italy.
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MeSH Terms
Carcinoma, Small Cell / pathology*
Cell Division / drug effects
Lung Neoplasms / pathology*
Mice, Nude
Neoplasm Invasiveness
Neoplasms, Experimental / pathology
Nerve Growth Factors / pharmacology*
Nicotine / pharmacology
Receptors, Nerve Growth Factor / metabolism*
Tumor Cells, Cultured
Reg. No./Substance:
0/Nerve Growth Factors; 0/Receptors, Nerve Growth Factor; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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