| Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy. | |
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MedLine Citation:
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PMID: 19064879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Juvenile myoclonic epilepsy (JME) is a syndrome of idiopathic generalized epilepsy (IGE) without structural brain abnormalities detectable by MRI or CT. OBJECTIVE: In the present study, we addressed the question of whether diffusion tensor MRI (DTI) can detect disease-specific white matter (WM) abnormalities in patients with JME. METHODS: We performed whole head DTI at 3 T in 10 patients with JME, 8 age-matched patients with cryptogenic partial epilepsy (CPE), and 67 age-matched healthy volunteers. Nerve fiber integrity was compared between the groups on the basis of optimized voxel-by-voxel statistics of fractional anisotropy (FA) maps obtained by DTI (analysis of covariance, categorical factor "group," covariate "age"). RESULTS: FA was reduced in a WM region associated with the anterior thalamus and prefrontal cortex in patients with JME compared to both control subjects and patients with CPE (p < 0.001). The patients with CPE showed normal values in this particular WM region. The FA reductions in the patients with JME correlated with the frequency of generalized tonic-clonic seizures (Spearman R = 0.54, p = 0.05). No significant correlations were found in the JME sample between FA reduction and the duration of antiepileptic medication. CONCLUSIONS: The results support the hypothesis that juvenile myoclonic epilepsy is associated with abnormalities of the thalamocortical network that can be detected by diffusion tensor MRI. |
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Authors:
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M Deppe; C Kellinghaus; T Duning; G Möddel; S Mohammadi; K Deppe; H Schiffbauer; H Kugel; S S Keller; E B Ringelstein; S Knecht |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 71 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-09 Completed Date: 2009-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 1981-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, University of Muenster, Albert-Schweitzer-Str. 33, 48129 Muenster, Germany. mail@Michael-Deppe.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anisotropy Brain Mapping Cerebral Cortex / pathology*, physiopathology Cognition Disorders / etiology, pathology, physiopathology Diffusion Magnetic Resonance Imaging Disease Progression Female Humans Male Myoclonic Epilepsy, Juvenile / pathology*, physiopathology Nerve Fibers, Myelinated / metabolism, pathology* Nerve Net / pathology, physiopathology Neural Pathways / pathology, physiopathology Predictive Value of Tests Prefrontal Cortex / pathology, physiopathology Seizures / pathology, physiopathology Thalamus / pathology*, physiopathology Wallerian Degeneration / etiology, pathology, physiopathology Young Adult |
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