Document Detail

Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy.
MedLine Citation:
PMID:  19064879     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Juvenile myoclonic epilepsy (JME) is a syndrome of idiopathic generalized epilepsy (IGE) without structural brain abnormalities detectable by MRI or CT. OBJECTIVE: In the present study, we addressed the question of whether diffusion tensor MRI (DTI) can detect disease-specific white matter (WM) abnormalities in patients with JME. METHODS: We performed whole head DTI at 3 T in 10 patients with JME, 8 age-matched patients with cryptogenic partial epilepsy (CPE), and 67 age-matched healthy volunteers. Nerve fiber integrity was compared between the groups on the basis of optimized voxel-by-voxel statistics of fractional anisotropy (FA) maps obtained by DTI (analysis of covariance, categorical factor "group," covariate "age"). RESULTS: FA was reduced in a WM region associated with the anterior thalamus and prefrontal cortex in patients with JME compared to both control subjects and patients with CPE (p < 0.001). The patients with CPE showed normal values in this particular WM region. The FA reductions in the patients with JME correlated with the frequency of generalized tonic-clonic seizures (Spearman R = 0.54, p = 0.05). No significant correlations were found in the JME sample between FA reduction and the duration of antiepileptic medication. CONCLUSIONS: The results support the hypothesis that juvenile myoclonic epilepsy is associated with abnormalities of the thalamocortical network that can be detected by diffusion tensor MRI.
M Deppe; C Kellinghaus; T Duning; G Möddel; S Mohammadi; K Deppe; H Schiffbauer; H Kugel; S S Keller; E B Ringelstein; S Knecht
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  71     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-09     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1981-5     Citation Subset:  AIM; IM    
Department of Neurology, University of Muenster, Albert-Schweitzer-Str. 33, 48129 Muenster, Germany.
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MeSH Terms
Brain Mapping
Cerebral Cortex / pathology*,  physiopathology
Cognition Disorders / etiology,  pathology,  physiopathology
Diffusion Magnetic Resonance Imaging
Disease Progression
Myoclonic Epilepsy, Juvenile / pathology*,  physiopathology
Nerve Fibers, Myelinated / metabolism,  pathology*
Nerve Net / pathology,  physiopathology
Neural Pathways / pathology,  physiopathology
Predictive Value of Tests
Prefrontal Cortex / pathology,  physiopathology
Seizures / pathology,  physiopathology
Thalamus / pathology*,  physiopathology
Wallerian Degeneration / etiology,  pathology,  physiopathology
Young Adult

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