Document Detail

Nerve decompression at the wrist in patients with Charcot-Marie-Tooth disease.
MedLine Citation:
PMID:  10654739     Owner:  NLM     Status:  MEDLINE    
Studies evaluating the effects of nerve release in patients with Charcot-Marie-Tooth disease have been extremely limited to date. This series attempts to evaluate the clinical and electrophysiologic effect of nerve release at the wrist in a series of patients with this disease. Five patients with documented Charcot-Marie-Tooth disease of the upper extremity were followed clinically and had nerve conduction testing both before and after surgery. This study shows that there was an improvement in both sensory and motor testing after release in a significant proportion of patients (p < 0.05). All patients documented improvement in their sensory latency response postoperatively (100 percent) and most showed improvement in motor latency responses (87 percent). More importantly, however, there seems to be an even greater clinical improvement in preoperative complaints (e.g., paresthesia and pain) in the majority of the extremities that underwent surgery with all patients experiencing initial relief and the majority showing no recurrence (63 percent) at last follow-up. From these results, this relief can be variable, but has lasted for a significant duration postoperatively in the majority, necessitating careful consideration for surgery as a legitimate option for patients with Charcot-Marie-Tooth.
C P Chalekson; R E Brown; D A Gelber; M J Haws
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  104     ISSN:  0032-1052     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2000-02-10     Completed Date:  2000-02-10     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  999-1002     Citation Subset:  AIM; IM    
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MeSH Terms
Charcot-Marie-Tooth Disease / physiopathology,  surgery*
Decompression, Surgical / methods*
Middle Aged
Nerve Compression Syndromes / physiopathology,  surgery*
Neural Conduction
Recovery of Function
Treatment Outcome
Wrist / innervation*,  physiopathology,  surgery*

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