Document Detail

Nerve conduction studies and prediction of mortality in hemodialysis patients.
MedLine Citation:
PMID:  18704818     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The electrophysiological aspects of uremic neuropathy have been studied extensively, but never for prediction of mortality. In order to assess the parameters of nerve conduction study (NCS) as predictors of mortality in hemodialysis patients, a post hoc analysis of a prospective observation study was made. METHODS: We examined conventional electrophysiological parameters (motor nerve conduction velocity [MCV], terminal latency [TL], and F wave latency of the peroneal nerve, as well as sensory nerve conduction velocity [SCV] of the sural nerve) in 75 nondiabetic patients. Hemodialysis modality (bicarbonate dialysis and biocompatible membranes), Kt/V, comorbidity (ischemic heart disease and congestive heart failure), and clinical and laboratory parameters were also evaluated. Survival was analyzed using the Cox proportional hazard model. RESULTS: SCV was significantly higher (t-test, p < 0.01) in the group of patients treated with polysulfone compared to those using cuprophane membranes. On the other hand, MCV significantly correlated with Kt/V (Pearson, r = 0.388; p < 0.01). Multivariate Cox regression revealed only MCV as a significant predictor of mortality in this group of hemodialysis patients (HR = 0.92; CI (0.86-0.99); p < 0.05). CONCLUSION: Only MCV was a significant mortality risk predictor among NCS parameters. This parameter correlates significantly with dialysis dose. SCV was related to the use of biocompatible membranes, indicating the complexity of polyneuropathy in dialysis patients.
Milan Stosovic; Ana Nikolic; Mirjana Stanojevic; Sanja Simic-Ogrizovic; Milan Radovic; Dijana Jovanovic; Zoran Popovic; Rajko Trikic; Ljubica Djukanovic
Related Documents :
18396098 - Natural evolution of carpal tunnel syndrome in untreated patients.
23543378 - Gray matter atrophy in progressive supranuclear palsy: meta-analysis of voxel-based mor...
12015768 - Lhermitte sign and urinary retention: atypical presentation of oxaliplatin neurotoxicit...
2084998 - Severe dysthyroid orbitopathy.
2372888 - Cardiac abnormalities in systemic lupus erythematosus. association with raised anticard...
10626198 - Serum levels of extracellular matrix in acute pancreatitis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  30     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-15     Completed Date:  2008-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  695-9     Citation Subset:  IM    
Institute of Urology and Nephrology, Clinic of Nephrology, Clinical Center of Serbia, Belgrade, Serbia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cause of Death
Electromyography / methods
Kidney Failure, Chronic / diagnosis,  mortality*,  therapy*
Middle Aged
Neural Conduction / physiology*
Peroneal Nerve / physiopathology
Polyneuropathies / diagnosis*,  epidemiology,  etiology*
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
Renal Dialysis / adverse effects*,  methods
Severity of Illness Index
Sural Nerve / physiopathology
Survival Analysis
Synaptic Transmission / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Analyses of subjects with hypokalemic metabolic alkolosis, Gitelman's and Bartter's syndrome.
Next Document:  Hemodialysis-induced left ventricular dysfunction is associated with an increase in ventricular arrh...