Nephrotoxicity of iodixanol versus iopamidol in patients with chronic kidney disease and diabetes mellitus undergoing coronary angiographic procedures.

Nephrotoxicity of iodixanol versus iopamidol in patients with chronic kidney disease and diabetes mellitus undergoing coronary angiographic procedures.

MedLine Citation:	PMID: 19853704 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	BACKGROUND: The choice of radiographic contrast media for use in patients at increased risk of contrast-induced nephropathy (CIN) is of ongoing interest. METHODS: The current study is a prospective, multicenter, randomized, double-blind design comparing the renal effects of the non-ionic, iso-osmolal agent, iodixanol, versus the non-ionic, low-osmolal agent, iopamidol, in 526 subjects with impaired baseline renal function (chronic kidney disease) and diabetes mellitus undergoing diagnostic and/or therapeutic coronary angiographic procedures. The co-primary end points were the peak increase in serum creatinine (SCr) and the incidence of CIN (increase > or =0.5 mg/dL) in SCr from baseline within 3 days of receiving contrast media. RESULTS: In 418 evaluable subjects with complete postcontrast media SCr data, the median peak increase in SCr in the iodixanol arm was 0.10 mg/dL, whereas in the iopamidol arm, the median peak increase was 0.09 mg/dL (P = .13). The overall CIN incidence was 10.5% (11.2% % in the iodixanol arm and 9.8% in the iopamidol arm, P = .7). The volume of contrast media, volume of saline administered, frequency of coronary interventional procedures, and severity of baseline kidney disease and of diabetes mellitus were similar between treatments. CONCLUSIONS: In the present study, the overall rate of CIN in patients with chronic kidney disease and DM undergoing coronary angiographic procedures was 10.5%. There was no significant difference between iodixanol and iopamidol in either peak increase in SCr or risk of CIN.

Authors:	Warren Laskey; Peter Aspelin; Charles Davidson; Michael Rudnick; Pierre Aubry; Sreenivas Kumar; Frank Gietzen; Marcus Wiemer;
Related Documents :	19140174 - Evaluation of hospital glycemic control at us academic medical centers. 8001624 - Pharmacology of alpha-glucosidase inhibition. 20485144 - Long-term follow-up of the metabolic profiles in obese patients with type 2 diabetes me... 6371274 - Ice cream in the diet of insulin-dependent diabetic patients. 21035764 - Glucose stimulation of hypothalamic mch neurons involves k(atp) channels, is modulated ... 16061124 - The effects of mobile phones on pacemaker function.
Publication Detail:	Type: Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Detail:	Title: American heart journal Volume: 158 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2009 Nov
Date Detail:	Created Date: 2009-10-26 Completed Date: 2009-12-31 Revised Date: 2010-02-23
Medline Journal Info:	Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States
Other Details:	Languages: eng Pagination: 822-828.e3 Citation Subset: AIM; IM
Affiliation:	Department of Medicine, University of New Mexico School of Medicine, Albuquerque, 87131, USA. wlaskey@salud.unm.edu
Data Bank Information
Bank Name/Acc. No.:	ClinicalTrials.gov/NCT00209430
Export Citation:	APA/MLA Format Download EndNote Download BibTex
MeSH Terms
Descriptor/Qualifier:	Aged Contrast Media / toxicity* Coronary Angiography / adverse effects* Creatinine / blood Diabetic Nephropathies / blood Double-Blind Method Female Humans Iopamidol / toxicity* Kidney Failure, Chronic / blood Male Triiodobenzoic Acids / toxicity*
Chemical
Reg. No./Substance:	0/Contrast Media; 0/Triiodobenzoic Acids; 60-27-5/Creatinine; 62883-00-5/Iopamidol; 92339-11-2/iodixanol
Investigator
Investigator/Affiliation:	Peter Aspelin / ; Knut Endresen / ; Victor Legrand / ; Claude Hanet / ; Willenbrock / ; Rainer Wessely / ; Marcus Wiemer / ; R?mi Sabatier / ; Ruth Strasser / ; Pierre Aubry / ; Azfar Zaman / ; Thorsten Dill / ; Eulogio Garc?a / ; Franscisco Fern?ndez-Avil?s / ; Paolo Rubartelli / ; Charles Knight / ; Joachim Sch?mmelfeder / ; Frank Gietzen / ; Franz-Josef Neumann / ; Jacques Boschat / ; Michael Rosseel / ; Marc Vincent / ; Mathias Vrolix / ; Ludwig Thierfelder / ; Stefan Sack / ; Antonio Manari / ; Nick Ossei-Gerning / ; Matthias R Schulze / ; Forster Tam?s / ; Lupkovics G?za / ; Apr? Dezs? / ; Tomasz Pasierski / ; Slawomir Dobrzycki / ; Waldemar Banasiak / ; Warren Laskey / ; Michelle Ratliff / ; Charles J Davidson / ; Michael Rudnick / ; Reda Ibrahim / ; Steven Rohrbeck / ; J Lawrence Stafford / ; Edward O McFalls / ; Kendrick Shunk / ; Frederick Weiland / ; Gary Schaer / ; J Huger Richardson / ; Peter C Nishan / ; Christian Bounds / ; Maurice Buchbinder / ; Jesse Goldman / ; Anthony Fung / ; John Hirshfeld / ; Joseph Moore / ; Steven Weisbord / ; Steven Weisbord / ; Lee A MacDonald / ; Anjali Acharya / ; John Colleran / ; V Seshiah / ; Vijay Viswanathan / ; Shreenivas Kumar / ; Parthap Kumar / ; Pramod Jaiswal /
Comments/Corrections
Comment In:	Am Heart J. 2010 Feb;159(2):e7; author reply e9 [PMID: 20152210 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document: Transradial versus transfemoral percutaneous coronary intervention in acute myocardial infarction Sy...
Next Document: Achieving routine sub 30 minute door-to-balloon times in a high volume 24/7 primary angioplasty cent...