Document Detail


Nephrotoxicity of iodixanol versus iopamidol in patients with chronic kidney disease and diabetes mellitus undergoing coronary angiographic procedures.
MedLine Citation:
PMID:  19853704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The choice of radiographic contrast media for use in patients at increased risk of contrast-induced nephropathy (CIN) is of ongoing interest. METHODS: The current study is a prospective, multicenter, randomized, double-blind design comparing the renal effects of the non-ionic, iso-osmolal agent, iodixanol, versus the non-ionic, low-osmolal agent, iopamidol, in 526 subjects with impaired baseline renal function (chronic kidney disease) and diabetes mellitus undergoing diagnostic and/or therapeutic coronary angiographic procedures. The co-primary end points were the peak increase in serum creatinine (SCr) and the incidence of CIN (increase > or =0.5 mg/dL) in SCr from baseline within 3 days of receiving contrast media. RESULTS: In 418 evaluable subjects with complete postcontrast media SCr data, the median peak increase in SCr in the iodixanol arm was 0.10 mg/dL, whereas in the iopamidol arm, the median peak increase was 0.09 mg/dL (P = .13). The overall CIN incidence was 10.5% (11.2% % in the iodixanol arm and 9.8% in the iopamidol arm, P = .7). The volume of contrast media, volume of saline administered, frequency of coronary interventional procedures, and severity of baseline kidney disease and of diabetes mellitus were similar between treatments. CONCLUSIONS: In the present study, the overall rate of CIN in patients with chronic kidney disease and DM undergoing coronary angiographic procedures was 10.5%. There was no significant difference between iodixanol and iopamidol in either peak increase in SCr or risk of CIN.
Authors:
Warren Laskey; Peter Aspelin; Charles Davidson; Michael Rudnick; Pierre Aubry; Sreenivas Kumar; Frank Gietzen; Marcus Wiemer;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  American heart journal     Volume:  158     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-26     Completed Date:  2009-12-31     Revised Date:  2010-02-23    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  822-828.e3     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of New Mexico School of Medicine, Albuquerque, 87131, USA. wlaskey@salud.unm.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00209430
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MeSH Terms
Descriptor/Qualifier:
Aged
Contrast Media / toxicity*
Coronary Angiography / adverse effects*
Creatinine / blood
Diabetic Nephropathies / blood
Double-Blind Method
Female
Humans
Iopamidol / toxicity*
Kidney Failure, Chronic / blood
Male
Triiodobenzoic Acids / toxicity*
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Triiodobenzoic Acids; 60-27-5/Creatinine; 62883-00-5/Iopamidol; 92339-11-2/iodixanol
Investigator
Investigator/Affiliation:
Peter Aspelin / ; Knut Endresen / ; Victor Legrand / ; Claude Hanet / ; Willenbrock / ; Rainer Wessely / ; Marcus Wiemer / ; R?mi Sabatier / ; Ruth Strasser / ; Pierre Aubry / ; Azfar Zaman / ; Thorsten Dill / ; Eulogio Garc?a / ; Franscisco Fern?ndez-Avil?s / ; Paolo Rubartelli / ; Charles Knight / ; Joachim Sch?mmelfeder / ; Frank Gietzen / ; Franz-Josef Neumann / ; Jacques Boschat / ; Michael Rosseel / ; Marc Vincent / ; Mathias Vrolix / ; Ludwig Thierfelder / ; Stefan Sack / ; Antonio Manari / ; Nick Ossei-Gerning / ; Matthias R Schulze / ; Forster Tam?s / ; Lupkovics G?za / ; Apr? Dezs? / ; Tomasz Pasierski / ; Slawomir Dobrzycki / ; Waldemar Banasiak / ; Warren Laskey / ; Michelle Ratliff / ; Charles J Davidson / ; Michael Rudnick / ; Reda Ibrahim / ; Steven Rohrbeck / ; J Lawrence Stafford / ; Edward O McFalls / ; Kendrick Shunk / ; Frederick Weiland / ; Gary Schaer / ; J Huger Richardson / ; Peter C Nishan / ; Christian Bounds / ; Maurice Buchbinder / ; Jesse Goldman / ; Anthony Fung / ; John Hirshfeld / ; Joseph Moore / ; Steven Weisbord / ; Steven Weisbord / ; Lee A MacDonald / ; Anjali Acharya / ; John Colleran / ; V Seshiah / ; Vijay Viswanathan / ; Shreenivas Kumar / ; Parthap Kumar / ; Pramod Jaiswal /
Comments/Corrections
Comment In:
Am Heart J. 2010 Feb;159(2):e7; author reply e9   [PMID:  20152210 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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