Document Detail

Nephrotoxicity of high and low osmolar contrast media: case control studies following digital subtraction angiography in potential risk patients.
MedLine Citation:
PMID:  2568816     Owner:  NLM     Status:  MEDLINE    
The urinary excretion of kidney-specific marker proteins before and 120 hours after intravenous injection of either high- or low-osmolar contrast media (CM; diatrizoate, iopamidol 370) was monitored in patients after digital vascular imaging. Inclusion criteria for the randomized clinical study in a total of 40 patients (15 women, 25 men; mean age, 64.5 years) were at least 50 years of age or diabetes mellitus with normal creatinine concentration in serum. Compared with the control period, the elimination of tubular indicator enzymes alanine aminopeptidase, gamma-glutamyltranspeptidase, alkaline phosphatase, as well as of glomerular localized angiotensinase A was significantly higher in all patients after injection of the CM. The most significant differences were observed after 48 hours. In contrast, lysosomal N-acetyl-beta-D-glucosaminidase activity in urine specimens reacted less clearly and appears to be a less sensitive parameter in assessing CM nephrotoxicity. Elimination of brush border as well as of glomerular marker proteins was significantly lower after intravenous injection of low-osmolar CM iopamidol 370 (832 mOsm/kg) than after meglumine diatrizoate 76 (2100 mOsm/kg). In all 40 patients a significant decrease in creatinine clearance was observed; however, patients receiving diatrizoate had a significant decrease in creatinine clearance (period 0 versus 24 to 48 hours after CM), whereas patients after administration of iopamidol had not. No difference was found between creatinine clearance after 48 hours of CM injection within both groups of CM. Due to noninvasive parameters of kidney damage nonionic, low-osmolar CM are less nephrotoxic in potential risk patients, and should be preferred to conventional CM.
J E Scherberich; A Fischer; E Rautschka; J Kollath; H Riemann
Related Documents :
2354386 - A comparative study of the nephrotoxicity of iohexol, iopamidol and ioxaglate in periph...
21115876 - Vascular function and circulating progenitor cells in thromboangitis obliterans (buerge...
19604146 - Propofol pharmacokinetics in patients with obstructive jaundice.
21412836 - Ventricular enlargement and mild cognitive impairment in early parkinson's disease.
15466086 - Clinical spectrum, morbidity, and mortality in 113 pediatric patients with mitochondria...
23639756 - Motor and non-motor symptoms of 1453 patients with parkinson's disease: prevalence and ...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin. Ergänzungsband     Volume:  128     ISSN:  0178-4609     ISO Abbreviation:  Fortschr Geb Rontgenstrahlen Nuklearmed Erganzungsbd     Publication Date:  1989  
Date Detail:
Created Date:  1989-08-17     Completed Date:  1989-08-17     Revised Date:  2008-02-26    
Medline Journal Info:
Nlm Unique ID:  0372776     Medline TA:  Fortschr Geb Rontgenstrahlen Nuklearmed Erganzungsbd     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  91-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Contrast Media / adverse effects*
Diabetic Nephropathies / complications*
Diatrizoate Meglumine / adverse effects*,  diagnostic use
Iopamidol / adverse effects*,  diagnostic use
Kidney / drug effects*
Middle Aged
Risk Factors
Subtraction Technique*
Reg. No./Substance:
0/Contrast Media; 131-49-7/Diatrizoate Meglumine; 62883-00-5/Iopamidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Renal excretion and computed tomography enhancement of iotrolan and iopamidol in dogs.
Next Document:  Renal and hepatic tolerance of nonionic and ionic contrast media in intravenous digital subtraction ...