Document Detail

Nephrotoxicity by dicloxacillin and gentamicin in 163 patients with intertrochanteric hip fractures.
MedLine Citation:
PMID:  10990387     Owner:  NLM     Status:  MEDLINE    
Of 163 patients with intertrochanteric hip fractures 87 received 2 g dicloxacillin and 240 mg of gentamicin preoperatively, and 76 patients had no antibiotic prophylaxis. Preoperative antibiotic prophylaxis was not shown to have any significant effect on wound infections. However, 16 reversible and 1 irreversible cases of kidney toxicity were found among patients receiving antibiotic prophylaxis, whereas there were only four cases of reversible kidney damage among the patients not receiving antibiotics.
L Solgaard; J I Tuxoe; M Mafi; S Due Olsen; T Toftgaard Jensen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International orthopaedics     Volume:  24     ISSN:  0341-2695     ISO Abbreviation:  Int Orthop     Publication Date:  2000  
Date Detail:
Created Date:  2000-12-15     Completed Date:  2001-01-04     Revised Date:  2013-04-12    
Medline Journal Info:
Nlm Unique ID:  7705431     Medline TA:  Int Orthop     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  155-7     Citation Subset:  IM    
Department of Orthopaedics, H:S Hvidovre Hospital, Hvidovre, Denmark.
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / adverse effects*
Antibiotic Prophylaxis*
Creatinine / blood
Dicloxacillin / adverse effects*
Gentamicins / adverse effects*
Hip Fractures / surgery*
Kidney Diseases / blood,  chemically induced*
Middle Aged
Penicillins / adverse effects*
Preoperative Care
Regression Analysis
Retrospective Studies
Statistics, Nonparametric
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins; 0/Penicillins; 3116-76-5/Dicloxacillin; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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