Document Detail

Nephrotoxic and hepatotoxic effects of trivalent and hexavalent chromium in a teleost fish Anabas scandens: enzymological and biochemical changes.
MedLine Citation:
PMID:  1282873     Owner:  NLM     Status:  MEDLINE    
The effects of trivalent and hexavalent chromium (Cr3+ and Cr6+) compounds on renal and hepatic respiratory enzymes and metabolites of a freshwater fish, Anabas scandens, were studied. In a subchronic exposure of 30 days, both forms of chromium inhibited the activities of lactate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, and isocitrate dehydrogenase, whereas the hexavalent form induced greater effects. The levels of pyruvate and lactate are not exactly reflected in lactate dehydrogenase activity.
N B Venugopal; S L Reddy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  24     ISSN:  0147-6513     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-17     Completed Date:  1993-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-93     Citation Subset:  IM    
Department of Zoology, Osmania University, Hyderabad, India.
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MeSH Terms
Chromium / toxicity*
Isocitrate Dehydrogenase / metabolism
Kidney / chemistry,  enzymology,  metabolism*
L-Lactate Dehydrogenase / metabolism*
Lactates / metabolism*
Liver / chemistry,  enzymology,  metabolism*
Malate Dehydrogenase / metabolism
Pyruvates / metabolism*
Succinate Dehydrogenase / metabolism*
Reg. No./Substance:
0/Lactates; 0/Pyruvates; 7440-47-3/Chromium; EC Dehydrogenase; EC Dehydrogenase; EC Dehydrogenase; EC Dehydrogenase

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