| Nephrotic syndrome with focal segmental glomerulosclerosis after an insect bite. | |
| | |
MedLine Citation:
|
PMID: 16939069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS AND METHODS: Focal segmental glomerulosclerosis (FSGS) is a glomerular disease defined by a characteristic histologic pattern that occurs either as a primary kidney disease (primary FSGS) or as a result of a systemic illness (secondary FSGS). Proteinuria, often in the nephrotic range, is the hallmark of FSGS. The occurrence of nephrotic syndrome after an insect sting is rarely reported in the literature. We present a case of nephrotic syndrome with focal segmental glomerulosclerosis with a glomerular tip lesion developing after an insect bite. RESULTS: A 51-year-old Caucasian female was bitten by an insect on her left leg, which immediately became swollen. Generalized edema developed and she was admitted for further investigations. Urinary 24-h protein excretion was 7 g. Percutaneous renal biopsy was performed and showed focal segmental glomerulosclerosis of the tip variant. Nephrotic syndrome was steroid-resistant, and when we added cyclophosphamide for 8 weeks complete remission was achieved. There was no relapse of the disease during the 2-month follow-up. CONCLUSIONS: This report demonstrates the useful role of cyclophosphamide in the treatment of steroid-resistant nephrotic syndrome due to FSGS with glomerular tip lesion. A causal relationship between the insect bite and the nephrotic syndrome is suggested and an immune response could be responsible for the nephrotic syndrome. |
| | |
Authors:
|
T Révai; I Kaszás; C Márton; G Arpási; G Winkler |
Related Documents
:
|
15071769 - Change of the course of steroid-dependent nephrotic syndrome after rituximab therapy. 17995529 - Pathogenesis of oedema in nephrotic syndrome: role of epithelial sodium channel. 19936659 - Bone mineral density in children with steroid-sensitive nephrotic syndrome. 9083769 - Nephrotic syndrome and hodgkin disease in children: a report of five cases. 12218329 - Nephrotic syndrome due to immunologically mediated hypocomplementic glomerulonephritis ... 3295719 - Forms of nephrotic syndrome more likely to progress to renal impairment. 16224109 - Posterior ankle impingement syndrome. 15071769 - Change of the course of steroid-dependent nephrotic syndrome after rituximab therapy. 16274859 - Pisiform ligament complex syndrome and pisotriquetral arthrosis. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Clinical nephrology Volume: 66 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-08-30 Completed Date: 2007-01-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: Germany |
Other Details:
|
Languages: eng Pagination: 128-30 Citation Subset: IM |
Affiliation:
|
Outpatient Department of Nephrology, St. John's Hospital, Budapest, Hungary. drrt@t-online.hu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cyclophosphamide
/
therapeutic use Female Glomerulosclerosis, Focal Segmental / drug therapy, etiology*, pathology Humans Immunosuppressive Agents / therapeutic use Insect Bites and Stings / complications* Middle Aged Nephrotic Syndrome / drug therapy, etiology*, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Concurrent anti-glomerular basement membrane disease and membranous glomerulonephritis: a case repor...
Next Document: Henoch-Schönlein purpura associated with acetaminophen and codeine.