| Nephrotic syndrome and interstitial nephritis associated with celecoxib. | |
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MedLine Citation:
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PMID: 12407655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nonsteroidal anti-inflammatory drugs (NSAIDs) are well known to cause fluid and electrolyte abnormalities and renal failure. NSAIDs also may cause an acute allergic interstitial nephritis (AIN) and the nephrotic syndrome, characterized by histologic pathology consistent with minimal change disease in patients with previously normal renal function. The nephrotoxic potential of cyclooxygenase 2 (COX-2) inhibitors has not been established because AIN associated with nephrotic syndrome has not been reported secondary to the COX-2 inhibitors. This case report describes the first case of AIN associated with nephrotic syndrome in a patient treated with the selective COX-2 inhibitor, celecoxib. |
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Authors:
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Arnold B Alper; Suzanne Meleg-Smith; N Kevin Krane |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 40 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-10-30 Completed Date: 2002-12-04 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1086-90 Citation Subset: IM |
Copyright Information:
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Copyright 2002 by the National Kidney Foundation, Inc. |
Affiliation:
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Department of Medicine, Section of Nephrology, Tulane University School of Medicine, New Orleans, LA 70112, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Anti-Inflammatory Agents, Non-Steroidal / adverse effects, therapeutic use Arthritis / drug therapy, enzymology Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors / adverse effects, therapeutic use Diabetes Mellitus, Type 2 / enzymology Glomerular Mesangium / enzymology, pathology, ultrastructure Humans Isoenzymes / antagonists & inhibitors Knee Joint / drug effects, pathology Male Membrane Proteins Microscopy, Electron Middle Aged Nephritis, Interstitial / chemically induced*, enzymology Nephrotic Syndrome / chemically induced*, enzymology Prostaglandin-Endoperoxide Synthases Pyrazoles Sulfonamides / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase 2 Inhibitors; 0/Cyclooxygenase Inhibitors; 0/Isoenzymes; 0/Membrane Proteins; 0/Pyrazoles; 0/Sulfonamides; 169590-42-5/celecoxib; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/PTGS2 protein, human; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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