| Nephrotic syndrome in a patient with IgA deficiency-associated mesangioproliferative glomerulonephritis. | |
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MedLine Citation:
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PMID: 10740809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case of mesangioproliferative glomerulonephritis in a 55-year-old woman with selective IgA deficiency and serum antinuclear antibodies who presented with nephrotic syndrome is described. The patient did not have clinical or laboratory features of systemic lupus erythematosus (SLE) other than antinuclear antibodies. Histology of the patient's renal biopsy revealed a mesangioproliferative glomerulonephritis and direct immunofluorescence showed that paramesangial deposits contained predominant IgM with lesser IgG, C3 and C1q. These findings are identical to those previously described in a form of glomerulonephritis associated with IgA deficiency and would be atypical for lupus nephritis. Glomerulonephritis is not a well recognized complication of IgA deficiency, though it has been rarely reported in the literature. This case provides further evidence that IgA deficiency is associated with a unique immune complex-mediated glomerulopathy with characteristic immunopathological and ultrastructural features. It is the first reported case to present with nephrotic syndrome. |
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Authors:
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M John; M Lam; B Latham; B Saker; M A French |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pathology Volume: 32 ISSN: 0031-3025 ISO Abbreviation: Pathology Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-05-12 Completed Date: 2000-05-12 Revised Date: 2006-10-31 |
Medline Journal Info:
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Nlm Unique ID: 0175411 Medline TA: Pathology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 56-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Immunology, Royal Perth Hospital, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Antinuclear Diagnosis, Differential Female Fluorescent Antibody Technique, Direct Glomerular Mesangium / metabolism, ultrastructure Glomerulonephritis, Membranoproliferative / etiology*, pathology Glomerulonephritis, Membranous / diagnosis Humans IgA Deficiency / complications*, pathology Immunoglobulin M / metabolism Lupus Nephritis / diagnosis Middle Aged Nephrotic Syndrome / etiology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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