Document Detail


Nephrotic syndrome in a patient with IgA deficiency-associated mesangioproliferative glomerulonephritis.
MedLine Citation:
PMID:  10740809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of mesangioproliferative glomerulonephritis in a 55-year-old woman with selective IgA deficiency and serum antinuclear antibodies who presented with nephrotic syndrome is described. The patient did not have clinical or laboratory features of systemic lupus erythematosus (SLE) other than antinuclear antibodies. Histology of the patient's renal biopsy revealed a mesangioproliferative glomerulonephritis and direct immunofluorescence showed that paramesangial deposits contained predominant IgM with lesser IgG, C3 and C1q. These findings are identical to those previously described in a form of glomerulonephritis associated with IgA deficiency and would be atypical for lupus nephritis. Glomerulonephritis is not a well recognized complication of IgA deficiency, though it has been rarely reported in the literature. This case provides further evidence that IgA deficiency is associated with a unique immune complex-mediated glomerulopathy with characteristic immunopathological and ultrastructural features. It is the first reported case to present with nephrotic syndrome.
Authors:
M John; M Lam; B Latham; B Saker; M A French
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pathology     Volume:  32     ISSN:  0031-3025     ISO Abbreviation:  Pathology     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-05-12     Completed Date:  2000-05-12     Revised Date:  2006-10-31    
Medline Journal Info:
Nlm Unique ID:  0175411     Medline TA:  Pathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  56-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Immunology, Royal Perth Hospital, Australia.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Antinuclear
Diagnosis, Differential
Female
Fluorescent Antibody Technique, Direct
Glomerular Mesangium / metabolism,  ultrastructure
Glomerulonephritis, Membranoproliferative / etiology*,  pathology
Glomerulonephritis, Membranous / diagnosis
Humans
IgA Deficiency / complications*,  pathology
Immunoglobulin M / metabolism
Lupus Nephritis / diagnosis
Middle Aged
Nephrotic Syndrome / etiology*,  pathology
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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