| Nephrotic syndrome in a child after umbilical-cord-blood transplantation. | |
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MedLine Citation:
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PMID: 16791603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a 12-year-old girl who developed nephrotic syndrome 6 months after umbilical-cord-blood transplantation (UCBT) for acute lymphoblastic leukemia (L2). In addition to nephrotic syndrome, she also showed autoimmune hemolytic anemia, thrombocytopenia and gastrointestinal symptoms. Since these symptoms were manifested during the course of tapering immunosuppressive agents, a diagnosis of chronic graft-versus-host disease (GVHD) was made. Findings from a kidney biopsy were compatible with minimal-change disease (MCD), and focal glomerular capillary thrombosis and mild tubular damage were also noted. She was treated with methylprednisolone pulse therapy followed by oral prednisolone. Proteinuria disappeared in 14 days. Gastrointestinal symptoms, anemia and thrombocytopenia were also corrected. This is a case report of nephrotic syndrome as a manifestation of chronic GVHD developed after stem-cell transplantation. A review of the cases reported in the literature is also made. |
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Authors:
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Joo Hoon Lee; Bo Sang Kwon; Il Soo Ha; Hae Il Cheong; Kyung Chul Moon; Hyo Seop Ahn; Yong Choi |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-06-22 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 21 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-09 Completed Date: 2006-12-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 1312-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Asan Medical Center, Seoul, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Cord Blood Stem Cell Transplantation* Female Graft vs Host Disease / immunology, prevention & control Humans Immunosuppressive Agents / pharmacology Male Middle Aged Nephrotic Syndrome / etiology, immunology, physiopathology* Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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