Document Detail

Nephrotic syndrome in 1st year of life and the role of unilateral nephrectomy.
MedLine Citation:
PMID:  1536734     Owner:  NLM     Status:  MEDLINE    
The study includes 17 infants with nephrotic syndrome. Their ages at the onset of disease ranged from 10 days to 10 months (median 2 months), and included 10 males and 7 females. Ten patients had consanguineous parents and 4 had a history of similar illness in the sibling. Renal biopsy revealed diffuse mesangial proliferation in 10 patients, diffuse mesangial sclerosis in 3, Finnish microcystic disease in 2, and focal segmental glomerulosclerosis and atypical glomerulopathy in 1 each. Unilateral nephrectomy was performed in 8 patients with intractable proteinuria associated with multiple complications. Five are well after 4-36 months follow-up, 1 died of septicaemia soon after the procedure, 1 needed dialysis and is stable at 26 months and 1 showed no reduction in the degree of proteinuria. We conclude that unilateral nephrectomy is a better alternative to bilateral nephrectomy in some infants with severe nephrotic syndrome.
T K Mattoo; A M al-Sowailem; M S al-Harbi; M A Mahmood; Y Katawee; M H Hassab
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  6     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-04-02     Completed Date:  1992-04-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  16-8     Citation Subset:  IM    
Maternity and Children's Hospital, Riyadh, Saudi Arabia.
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MeSH Terms
Follow-Up Studies
Infant, Newborn
Nephrotic Syndrome / congenital,  genetics,  surgery*
Proteinuria / surgery,  therapy
Treatment Outcome

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