| Nephrotic syndrome due to primary systemic AL amyloidosis, successfully treated with VAD (vincristine, doxorubicin and dexamethasone) alone. | |
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MedLine Citation:
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PMID: 18344643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report 3 patients with nephrotic syndrome ascribed to primary systemic AL amyloidosis that were successfully treated with VAD (vincristine, doxorubicin and dexamethasone) alone. M-protein in serum disappeared soon after VAD, and nephrotic syndrome gradually improved in parallel with a decrease in daily protein excretion in urine. Long-term follow-up of these patients showed neither relapse of nephrotic syndrome nor reappearance of M-protein. High-dose melphalan followed by autologous stem cell support is a standard therapy for primary systemic AL amyloidosis, but in high-risk cases for this treatment, such as elderly patients and those with multiple organ involvement, VAD might be a therapeutic option. |
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Authors:
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Masayuki Matsuda; Takahisa Gono; Nagaaki Katoh; Takuhiro Yoshida; Ko-Ichi Tazawa; Yasuhiro Shimojima; Wataru Ishii; Tomohisa Fushimi; Shu-Ichi Ikeda |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-17 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 47 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-03-17 Completed Date: 2008-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 543-9 Citation Subset: IM |
Affiliation:
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Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto. matsuda@hsp.md.shinshu-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amyloidosis / complications* Antineoplastic Combined Chemotherapy Protocols / administration & dosage, therapeutic use* Dexamethasone / administration & dosage Doxorubicin / administration & dosage Female Humans Male Middle Aged Nephrotic Syndrome / diagnosis, drug therapy*, etiology* Vincristine / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/VAD I protocol; 23214-92-8/Doxorubicin; 50-02-2/Dexamethasone; 57-22-7/Vincristine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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