Document Detail


Nephrotic syndrome due to immunologically mediated hypocomplementic glomerulonephritis in a patient of Waldenström's macroglobulinemia.
MedLine Citation:
PMID:  12218329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 72-year-old man was diagnosed as having nephritic syndrome complicated by Waldenström's macroglobulinemia (WM). A monoclonal IgM lambda protein and decreased serum complements were observed. The renal biopsy disclosed the capillary occluded by thrombi which was stained with IgG, IgA, IgM, C4, lambda light chain and slight kappa light chain in a granular pattern. Electron dense deposits were noted in the subendothelial spaces. An unusual case of WM who developed nephrotic syndrome due to immunologically mediated hypocomplementic glomerulonephritis is described.
Authors:
Souichiro Haraguchi; Yoshiyuki Tomiyoshi; Shigehisa Aoki; Takanobu Sakemi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nephron     Volume:  92     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-09     Completed Date:  2003-03-03     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  452-5     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Affiliation:
Department of Internal Medicine, Saga Medical School, Nabeshima 5-1-1, Saga 849-8501, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Complement C4 / deficiency
Complement System Proteins / deficiency*
Glomerulonephritis / complications*,  immunology,  pathology
Humans
Immunoglobulin M / metabolism
Immunoglobulin lambda-Chains / metabolism
Male
Microscopy, Electron
Nephrotic Syndrome / etiology*,  immunology,  pathology
Waldenstrom Macroglobulinemia / complications*,  immunology,  pathology
Chemical
Reg. No./Substance:
0/Complement C4; 0/Immunoglobulin M; 0/Immunoglobulin lambda-Chains; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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