| Nephrotic syndrome caused by protein thrombi in glomerulocapillary lumen in Waldenström's macroglobulinaemia. | |
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MedLine Citation:
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PMID: 11054074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Waldenström's macroglobulinaemia (WM) is described as a disorder of plasmacytoid lymphocytes. The renal complications of WM are less common and severe than those of multiple myeloma. We present a case of WM complicated by nephrotic syndrome. A biopsy specimen of the kidney revealed the intraglomerular thrombi of immunoglobulin M paraprotein. Corticosteroid pulse therapy and plasmapheresis were effective in improving proteinuria and reducing protein thrombi. The nephrotic syndrome caused by protein thrombi in WM may be reversible, at least in its early stage. |
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Authors:
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Y Harada; N Ido; T Okada; M Otani; T Shirota; T Nakao; T Hayashi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: British journal of haematology Volume: 110 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-11-09 Completed Date: 2000-11-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 880-3 Citation Subset: IM |
Affiliation:
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The Third Department of Internal Medicine, Tokyo Medical University Hospital, Tokyo, Japan. yharada@tokyo-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Fluorescent Antibody Technique Glucocorticoids / therapeutic use Humans Immunoglobulin M / analysis Kidney Glomerulus / pathology Male Methylprednisolone / therapeutic use Nephrotic Syndrome / drug therapy, etiology*, therapy Paraproteins / analysis Plasmapheresis Thrombosis / complications, pathology Waldenstrom Macroglobulinemia / complications*, drug therapy, therapy |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Immunoglobulin M; 0/Paraproteins; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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