| Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis. | |
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MedLine Citation:
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PMID: 17009081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 43-year-old woman with multiple sclerosis (MS) had nephrotic syndrome 21 months after starting treatment with interferon (IFN)-beta-1b (subcutaneous administration). She had taken no drug except for the IFN-beta-1b. Because nephrotic syndrome may be induced by IFN therapy, the IFN was stopped. Percutaneous renal biopsy revealed that she had minimal change nephrotic syndrome. As nephrotic-range proteinuria, hypoalbuminemia, and general edema were worsening even 2 weeks after cessation of the drug, oral corticosteroid therapy (prednisolone 40 mg/day) was started. The nephrotic syndrome was treated successfully with prednisolone. The dosage of prednisolone was tapered, without a relapse, and then the corticosteroid therapy was stopped. IFN-beta-1b therapy was then resumed, and the patient is in remission for both nephrotic syndrome and MS. Though proteinuria and nephrotic syndrome is a rare adverse effect of IFN-beta-1b therapy, physicians treating MS patients with this agent should pay careful attention to new clinical symptoms and laboratory findings. |
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Authors:
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Ryuichiro Kumasaka; Norio Nakamura; Kenichi Shirato; Takeshi Fujita; Reiichi Murakami; Michiko Shimada; Masayuki Nakamura; Hiroshi Osawa; Hideaki Yamabe; Ken Okumura |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical and experimental nephrology Volume: 10 ISSN: 1342-1751 ISO Abbreviation: Clin. Exp. Nephrol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-29 Completed Date: 2006-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709923 Medline TA: Clin Exp Nephrol Country: Japan |
Other Details:
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Languages: eng Pagination: 222-5 Citation Subset: IM |
Affiliation:
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The Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan. rkuma-cc@umin.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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adverse effects*,
therapeutic use Adult Biopsy Female Glucocorticoids / therapeutic use Humans Interferon-beta / adverse effects*, therapeutic use Kidney / pathology Multiple Sclerosis / drug therapy* Nephrosis, Lipoid / chemically induced*, drug therapy, pathology Prednisolone / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Glucocorticoids; 145155-23-3/interferon beta-1b; 50-24-8/Prednisolone; 77238-31-4/Interferon-beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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