| Nephrotic syndrome associated with chronic lymphocytic leukemia resistant to immunosuppressive drugs: remission obtained by splenectomy. | |
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MedLine Citation:
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PMID: 8861805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic lymphocytic leukemia is a common disease in the elderly but is rarely associated with a nephrotic syndrome. The rarity of this association suggests that leukemic cells may have certain properties or features that may lead to the development of glomerulonephritis. Effective medical treatment of the leukemia may not necessarily allow regression of the nephrotic syndrome; however, the effects of splenectomy on nephrotic proteinuria when associated to chronic lymphocytic leukemia have never been evaluated. We report the case of a 50-year-old male with stage C CD5+ chronic lymphocytic leukemia associated with a nephrotic syndrome due to Type I membranoproliferative glomerulonephritis. Chlorambucil and prednisone were unable to control the leukemia and the nephrotic range proteinuria, and were discontinued because of poor hematologic tolerance. A splenectomy immediately resulted in a spectacular remission of both chronic lymphocytic leukemia and the nephrotic syndrome. Spleen lymphocytes were collected and tested in quantitative flow cytometry for the expression of the main B cell associated markers. They did not exhibit any particular immunophenotypic pattern. This report of a remission of a glomerulonephritis associated with chronic leukemia following splenectomy is evidence of a possible relationship between the two diseases. |
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Authors:
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J M Halimi; T Lavabre-Bertrand; J J Beraud; B Canaud |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Clinical nephrology Volume: 45 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1997-05-19 Completed Date: 1997-05-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 273-6 Citation Subset: IM |
Affiliation:
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Service de Reanimation chez des Maladies Metaboliques, Hopital Lapeyronie, Montpellier, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Glomerulonephritis, Membranoproliferative
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drug therapy,
etiology*,
surgery* Humans Immunosuppressive Agents / therapeutic use* Leukemia, Lymphocytic, Chronic, B-Cell / complications*, drug therapy Male Middle Aged Nephrotic Syndrome / drug therapy, etiology*, surgery* Splenectomy* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents |
| Comments/Corrections | |
Comment In:
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Clin Nephrol. 1997 Feb;47(2):131-3
[PMID:
9049465
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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