| Nephrotic syndrome as a complication of anti-TNFalpha in a patient with rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 12852723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a patient with rheumatoid arthritis (RA) who developed a nephrotic syndrome during treatment with a fully human recombinant monoclonal antibody against TNFalpha (adalimumab, Humira, Abbott). The proteinuria disappeared spontaneously after cessation of anti-TNFalpha treatment and relapsed after rechallenge, pointing to anti-TNFalpha as the culprit. Although renal biopsy disclosed a membranous glomerulopathy, the clinical picture was more compatible with minimal lesion glomerulopathy. The pathogenesis of this side effect is not clear; several mechanisms could in theory lead to these abnormalities. |
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Authors:
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A A den Broeder; K J M Assmann; P L C M van Riel; J F M Wetzels |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Netherlands journal of medicine Volume: 61 ISSN: 0300-2977 ISO Abbreviation: Neth J Med Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-07-10 Completed Date: 2003-07-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 137-41 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands. alfonsenellen.broeder@hccnet.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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adverse effects*,
therapeutic use Arthritis, Rheumatoid / drug therapy* Humans Male Middle Aged Nephrotic Syndrome / etiology* Tumor Necrosis Factor-alpha / antagonists & inhibitors*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Tumor Necrosis Factor-alpha; 0/adalimumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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