Document Detail

Nephrotic syndrome as a clinical manifestation of systemic sclerosis.
MedLine Citation:
PMID:  17429639     Owner:  NLM     Status:  MEDLINE    
We have described the unusual case of coexistence of membranous nephropathy resulting in nephrotic syndrome with systemic sclerosis. A 60-year-old patient was admitted to the Department of Nephrology with marked proteinuria and oedema. The renal biopsy specimen disclosed the features characteristic of membranous glomerulonephritis. The patient was treated with chlorambucil for 1 month followed by prednisone for 1 month. However, her condition still did not improve. Therefore, the other causes of nephrotic syndrome were investigated. Once anti-Scl-70 antibody was detected the patient was transferred to the Department of Rheumatology and Connective Tissue Diseases. Physical examination revealed Raynaud phenomenon, sclerodactylia, thickened skin of the chest and back. The patient was diagnosed with diffuse systemic sclerosis. The cyclophosphamide therapy was instituted and the patient's condition improved.
Ewa Wielosz; Maria Majdan; Dorota Suszek; Iwona Smarz-Widelska; Agnieszka Korolczuk; Elzbieta Korobowicz
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-04-11
Journal Detail:
Title:  Rheumatology international     Volume:  27     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-09     Completed Date:  2008-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1087-9     Citation Subset:  IM    
Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland.
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MeSH Terms
Glomerular Basement Membrane / pathology
Glomerulonephritis, Membranous / complications*,  pathology
Middle Aged
Nephrotic Syndrome / etiology*
Scleroderma, Systemic / complications*,  diagnosis*

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