Document Detail

Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal.
MedLine Citation:
PMID:  10037059     Owner:  NLM     Status:  MEDLINE    
GVHD is one of the most frequent complications of BMT and recently nephrotic syndrome (NS) has been described as a manifestation of chronic GVHD. Here, we present an AA patient who developed NS 1 year after BMT when cyclosporine was stopped. Renal biopsy showed focal sclerosis associated with membranous deposits. He also had other clinical manifestations of chronic GVHD: sicca-like syndrome and colestasis. After 15 days of CsA therapy, he experienced a remarkable improvement in the NS and GVHD as a whole. We comment on immunological mechanisms that could be involved in the pathogenesis of this manifestation.
J S Oliveira; D Bahia; M Franco; C Balda; S Stella; J Kerbauy
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  23     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-06-01     Completed Date:  1999-06-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  99-101     Citation Subset:  IM    
Department of Hematology, EPM/UNIFESP, São Paulo, Brazil.
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MeSH Terms
Bone Marrow Transplantation / adverse effects*
Cyclosporine / therapeutic use*
Graft vs Host Disease / complications*,  drug therapy
Immunosuppressive Agents / therapeutic use*
Nephrotic Syndrome / etiology*,  physiopathology
Transplantation, Homologous
Reg. No./Substance:
0/Immunosuppressive Agents; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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