| Nephrotic syndrome and acute renal failure in non-Hodgkin lymphoplasmacytic lymphoma. | |
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MedLine Citation:
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PMID: 18214715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two patients with lymphoplasmacytic lymphoma, and monoclonal proteins of IgM in one, and IgG and lambda light chains in the second patient, nephrotic syndrome and acute renal failure are reported. A 58-year-old man previously treated for pre-B acute lymphoblastic leukemia, developed 3 years later nephrotic syndrome as a complication of lymphoplasmacytic lymphoma and high-paraprotein IgM kappa type. Immunofluorescent analysis of kidney biopsy showed extensive IgM and light kappa chain deposits, which caused membranoproliferative glomerulonephritis. Treatment with cyclophosphamide was ineffective and patient died 2 months later. The second patient is a 42-year-old female diagnosed with lymphoplasmacytic lymphoma and paraprotein IgG lambda type. The course of the disease was fulminant with developing nephrotic syndrome and fatal acute renal failure. Immunofluorescent and light microscopic studies of kidney biopsy showed signs of immunotactoid glomerulonephritis with deposits of IgG and C3. Hemodyalises and cytostatic therapy were without response and she died after 45 days. |
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Authors:
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Natasa Colović; Tatjana Terzić; Bosko Andelić; Mirjana Sretenović; Biljana Mihaljević; Jasmina Marković Lipkovski; Milica Colović |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-24 |
Journal Detail:
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Title: Medical oncology (Northwood, London, England) Volume: 25 ISSN: 1357-0560 ISO Abbreviation: Med. Oncol. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-12-01 Completed Date: 2009-03-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9435512 Medline TA: Med Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 458-61 Citation Subset: IM |
Affiliation:
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Institute of Hematology, Clinical Center of Serbia, Belgrade, Serbia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Fatal Outcome Female Fluorescent Antibody Technique Humans Immunoglobulin G Immunoglobulin M Immunohistochemistry Kidney Failure, Acute / complications*, pathology, physiopathology Lymphoma, Non-Hodgkin / complications*, pathology, physiopathology Male Middle Aged Nephrotic Syndrome / complications*, pathology, physiopathology Waldenstrom Macroglobulinemia / complications*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G; 0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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