| Nephrotic syndrome and acute interstitial nephritis associated with the use of diclofenac. | |
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MedLine Citation:
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PMID: 10444806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Commonly reported renal complications of non-steroidal anti-inflammatory drugs (NSAID) include acute renal failure and/or acute interstitial nephritis; in rare cases a nephrotic syndrome was also observed. In most cases this was due to the development of secondary membranous nephropathy. Following withdrawal of the drug the nephrotic syndrome usually resolved rapidly. We report a 65-year-old woman who developed a nephrotic syndrome and acute renal failure during 6 months of treatment with the NSAID diclofenac. Renal biopsy revealed both, membranous nephropathy and interstitial nephritis. After discontinuation of diclofenac and treatment with prednisone 1 mg/kg/day, furosemide 400 mg/day and simvastatin at a dose of 20 mg/day, creatinine clearance gradually increased and after 5 months of treatment complete remission of the nephrotic syndrome was observed. |
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Authors:
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T Révai; G Harmos |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Wiener klinische Wochenschrift Volume: 111 ISSN: 0043-5325 ISO Abbreviation: Wien. Klin. Wochenschr. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-09-27 Completed Date: 1999-09-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 21620870R Medline TA: Wien Klin Wochenschr Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 523-4 Citation Subset: IM |
Affiliation:
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Department of Nephrology St. János Hospital, Budapest, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Diclofenac / adverse effects* Female Humans Nephritis, Interstitial / chemically induced*, diagnosis, pathology Nephrotic Syndrome / chemically induced*, diagnosis, pathology |
| Chemical | |
Reg. No./Substance:
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15307-86-5/Diclofenac |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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