| Nephrotic syndrome accompanying familial hemophagocytic syndrome. | |
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MedLine Citation:
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PMID: 8846138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We describe the first reported case of familial hemophagocytic syndrome (FHS) with concurrent minimal change nephrotic syndrome (MCNS). PATIENTS AND METHODS: This is a case report of a 30-month-old girl who presented to Children's Memorial Hospital with pancytopenia and heavy proteinuria. RESULTS: This patient presented with anemia, neutropenia, thrombocytopenia, hypertriglyceridemia, and proteinuria. A brother died at 2 months of age with similar findings. A bone marrow biopsy demonstrated histiocyte proliferation with marked erythrophagocytosis, consistent with FHS. Treatment was begun with corticosteroids and VP-16. The patient developed worsening peripheral edema and hypoalbuminemia, with heavy proteinuria. After 1 month of therapy with persistence of heavy proteinuria, a renal biopsy was performed, the results of which were consistent with MCNS. CONCLUSION: This is the first reported case of FHS with coincident MCNS. |
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Authors:
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M C Braun; R A Cohn; M Kletzel |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 18 ISSN: 1077-4114 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-10-21 Completed Date: 1996-10-21 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 195-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Northwestern University Medical School, Chicago, Illinois, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Female Histiocytosis, Non-Langerhans-Cell / complications* Humans Nephrotic Syndrome / complications* |
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