Document Detail

Nephrotic-range proteinuria in a patient with a renal allograft treated with sorafenib for metastatic renal-cell carcinoma.
MedLine Citation:
PMID:  19381758     Owner:  NLM     Status:  MEDLINE    
A 51-year-old man with immunoglobulin A (IgA) nephropathy developed metastatic renal-cell carcinoma of his native right kidney, 3.5 years post kidney transplant. At that time renal function was stable with the presence of only mild proteinuria. Shortly after chemotherapy with sorafenib [anti-vascular endothelial growth factor (VEGF)] was initiated, progressive renal impairment, hypertension, and nephrotic-range proteinuria developed. Allograft biopsy showed extensive IgA nephropathy. After withdrawal of the anti-VEGF therapy, however, renal function and blood pressure improved, and proteinuria diminished. Based on the clinical course and histopathological findings we hypothesize that sorafenib may induce nephrotic-range proteinuria and renal impairment, possibly through anti-VEGF-mediated effects on the progression of IgA nephropathy.
Iris J A M Jonkers; Marjolijn van Buren
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-04-21
Journal Detail:
Title:  Clinical and experimental nephrology     Volume:  13     ISSN:  1437-7799     ISO Abbreviation:  Clin. Exp. Nephrol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-06     Completed Date:  2009-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709923     Medline TA:  Clin Exp Nephrol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  397-401     Citation Subset:  IM    
Department Nephrology C3-R, Leiden University Medical Center, Albinusdreef 2, Leiden 2300 RC, The Netherlands.
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MeSH Terms
Angiogenesis Inhibitors / adverse effects*
Antihypertensive Agents / therapeutic use
Benzenesulfonates / adverse effects*
Carcinoma, Renal Cell / drug therapy*,  secondary
Disease Progression
Glomerulonephritis, IGA / chemically induced,  complications*,  pathology
Hypertension / chemically induced,  drug therapy
Kidney Neoplasms / drug therapy*,  secondary
Kidney Transplantation*
Middle Aged
Nephrotic Syndrome / chemically induced*,  pathology
Proteinuria / chemically induced*,  pathology
Pyridines / adverse effects*
Transplantation, Homologous
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antihypertensive Agents; 0/Benzenesulfonates; 0/Pyridines; 0/sorafenib

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