| Nephrotic edema--pathogenesis and treatment. | |
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MedLine Citation:
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PMID: 8328511 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardinal features of the nephrotic syndrome are albuminuria, hypoalbuminemia, and edema. Traditionally, albuminuria was thought to be responsible primarily for the development of hypoalbuminemia. A decreased plasma-albumin concentration accompanied by a decreased plasma-oncotic pressure was thought responsible for the development of edema and secondary salt retention by the kidney. However, new findings have prompted a reevaluation of these relationships. For example, increased renal catabolism and blunted hepatic synthesis appear to play major roles in the development of hypoalbuminemia. Evidence suggests that primary, rather than secondary, salt retention by the kidney and activation of mechanisms that limit fluid movement across the capillary wall participate in the pathogenesis of the nephrotic syndrome and related edema. The treatment of patients with the nephrotic syndrome should limit proteinuria. This can be accomplished by administering angiotensin-converting enzyme inhibitors, lowering the protein content of the diet, and cautiously using non-steroidal antiinflammatory agents. |
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Authors:
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B F Palmer |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 306 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-08-06 Completed Date: 1993-08-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 53-67 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albuminuria Angiotensin-Converting Enzyme Inhibitors / therapeutic use Blood Volume Dietary Proteins Edema / etiology* Humans Kidney Function Tests Liver / metabolism Nephrectomy Nephrotic Syndrome / blood, physiopathology*, therapy* Proteinuria Serum Albumin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Dietary Proteins; 0/Serum Albumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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