Document Detail

Nephropathy associated with antiphospholipid antibodies in patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  21486929     Owner:  NLM     Status:  Publisher    
Abstract: Background. Nephropathy associated with antiphospholipid antibodies (aPL) has been proposed as a risk factor of worse renal prognosis in patients with systemic lupus erythematosus (SLE). The purpose of the current study was to evaluate the prevalence of aPL-associated nephropathy (aPLN) among patients with lupus nephritis and to describe their functional renal outcome. Methods. A total of 79 renal biopsies from 77 patients followed at the Hospital Clinic, Spain were analysed. Each renal biopsy was evaluated by a pathologist who was blinded to the aPL status. Thrombotic microangiopathy (TMA), fibrous intimal hyperplasia (FIH), fibrocellular arterial occlusion (FAO), focal cortical atrophy (FCA), and tubular thyroidization as lesions suggestive of aPLN were identified. Results: aPLN was found in nine (11.4%) biopsies. TMA was found in three (33.3%) cases whereas chronic aPLN, represented by FIH and FCA, was found in four (44.4%) and three (33.3%) cases, respectively. A significant association between the presence of aPL and aPLN was found (p = 0.003). Patients with lupus anticoagulant (LA) plus IgG anticardiolipin antibodies (aCL) showed an increased prevalence of aPLN (OR: 3.61, 95% CI 1.28-5.14; p = 0.002). Creatinine levels were significantly increased in patients with aPLN compared with those with aPL without aPLN (p = 0.038). However, no significant difference in complete remission, partial remission, not response, and established renal damage between groups was observed at the end of follow-up. Conclusions: The aPL have an important role in the pathogenesis of renal lesions in SLE patients. Prospective studies are needed to address the role of aPLN in the long-term outcome of SLE patients with positive aPL.
R Silvariño; F Sant; G Espinosa; G Pons-Estel; M Solé; R Cervera; P Arrizabalaga
Related Documents :
24053709 - Risk factors associated with poor controlled pediatric asthma in a university hospital.
6849489 - Preoperative recognition of intestinal strangulation obstruction. prospective evaluatio...
6431389 - Bacterial contamination of the small intestine as an important cause of chronic diarrhe...
2434019 - Oculomasticatory myorhythmia: a unique movement disorder occurring in whipple's disease.
20437129 - Usefulness of computed tomography enteroclysis in the intestinal tract.
11515679 - Fibromyalgia in patients with irritable bowel syndrome. an association with the severit...
25366709 - Functional imaging in pre-motor parkinson's disease.
21243249 - Incidence of sudep in a cohort of patients with refractory epilepsy: the role of surger...
19779329 - Hypothyroidism following hemithyroidectomy: a retrospective review.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-12
Journal Detail:
Title:  Lupus     Volume:  -     ISSN:  1477-0962     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Autoimmune Diseases, Hospital Clínic-Institut d'Investigacions Biomèdiques Pi i Sunyer (IDIBAPS); Universitat de Barcelona; Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A hundred-year-old question: is the moss calyptra covered by a cuticle? A case study of Funaria hygr...
Next Document:  Harmful Alcohol Habits were No More Common in a Sample of Newly Sick-Listed Swedish Women and Men Co...