Document Detail


Nephron stop-flow pressure response to obstruction for 24 hours in the rat kidney.
MedLine Citation:
PMID:  4825239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Complete ureteral ligation of 24-h duration significantly reduced stop-flow and estimated glomerular capillary pressures in nephrons accessible to micropuncture in obstructed kidneys. In kidneys without ureteral obstruction, a similar response occurred in single tubules blocked for 24 h without affecting nearby unblocked tubules. Thus, the response to tubular obstruction occurs on an individual nephron basis and results from constriction of individual afferent arterioles. The mechanism leading to the response is unknown, but a feedback mechanism operating through the juxtaglomerular apparatus of individual nephrons is an attractive possibility.
Authors:
W J Arendshorst; W F Finn; C W Gottschalk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  53     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1974 May 
Date Detail:
Created Date:  1974-06-26     Completed Date:  1974-06-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1497-500     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Feedback
Kidney / physiology*
Ligation
Male
Nephrons / physiology
Rats
Ureter / physiology
Comments/Corrections

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