| Nephrolithiasis in medullary sponge kidney: evaluation of clinical and metabolic features. | |
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MedLine Citation:
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PMID: 22014971 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Medullary sponge kidney (MSK) is a disorder characterized by tubular dilation of renal collecting ducts and cystic dilation of medullary pyramids that has been associated with stone disease. The significance of nephrolithiasis and the mechanisms by which it occurs are incompletely understood. We describe clinical and metabolic features of nephrolithiasis in a cohort of patients with MSK. METHODS: Records were reviewed of 56 patients, all with radiographic diagnosis of medullary sponge kidney and data collected pertaining to presentation, stone events and recurrences, stone composition, and metabolic profile to perform a descriptive study with median 3.7 years follow-up. RESULTS: Nephrolithiasis was confirmed radiographically in 39/56 patients (69.6%). No patient without evidence of nephrolithiasis developed a stone event, whereas 13/39 (33%) of those with nephrolithiasis developed a recurrent stone event. Stones were composed of calcium oxalate monohydrate, calcium oxalate dihydrate, calcium phosphate apatite, and uric acid. Metabolic profile was obtained for 26 of 39 (67%) stone-forming patients demonstrating abnormalities in 22/26 (84.6%). These included hypercalciuria, 58% (15/26); low urine volume, 35% (9/26); hyperuricosuria, 27% (7/26); hypocitraturia, 19% (5/26); elevated urine sodium, 15% (4/26); and hyperoxaluria, 12% (3/26). CONCLUSION: Many patients with MSK have no evidence of nephrolithiasis. Among those who do, recurrence is common, and metabolic profile and composition are varied as in the general stone-forming population. |
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Authors:
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E Fred McPhail; Matthew T Gettman; David E Patterson; Laureano J Rangel; Amy E Krambeck |
Publication Detail:
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Type: Journal Article Date: 2011-10-19 |
Journal Detail:
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Title: Urology Volume: 79 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-07 Completed Date: 2012-05-17 Revised Date: 2013-01-22 |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: United States |
Other Details:
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Languages: eng Pagination: 277-81 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Citric Acid / urine Diuresis Female Humans Hypercalciuria / complications Hyperoxaluria / complications Kidney Calculi / chemistry Male Medullary Sponge Kidney / complications*, metabolism, radiography Middle Aged Natriuresis Nephrolithiasis / blood, etiology*, radiography Recurrence Retrospective Studies Uric Acid / urine Young Adult |
| Chemical | |
Reg. No./Substance:
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69-93-2/Uric Acid; 77-92-9/Citric Acid |
| Comments/Corrections | |
Comment In:
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Urology. 2012 Dec;80(6):1395-6
[PMID:
23206796
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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