Document Detail

Nephrogenic systemic fibrosis associated with gadolinium use.
MedLine Citation:
PMID:  18400614     Owner:  NLM     Status:  MEDLINE    
Nephrogenic systemic fibrosis (NSF) is an idiopathic, progressive, systemic fibrosis that occurs in patients with renal diseases. Recently, gadolinium-containing contrast (Gd-contrast) has become a suspected causal factor for NFS. This report discusses two female patients with end-stage renal disease, aged 70 and 51 years, respectively, who developed histologically proven NSF after exposure to Gd-contrast. Clinically, both patients were characterized by fibrosis and induration of skin and muscle mainly in the limbs with joint contracture. In the first case, NSF developed gradually after undergoing evaluation by Gd-contrast magnetic resonance imaging (MRI) and subsequent surgery for her urothelial carcinoma. In the second patient, NSF developed after undergoing evaluation by Gd-contrast MRI for her right shoulder bursitis with calcification, and the conditions of NSF continued to worsen after the surgical treatment of this right shoulder lesion. Although the role of Gd-contrast in NSF is still not well known, the correlation in our cases strongly suggests that it should be used with cautioned in patients with end-stage renal disease. Both of our patients underwent surgery before or during the development of NSF, indicating that the surgical procedure may be a contributing factor.
Chi-Chao Chao; Chih-Chao Yang; Cheng-Hsiang Hsiao; Ming-Kai Pan; Chin-Hsuan Lin; Sung-Tsang Hsieh
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  107     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  270-4     Citation Subset:  IM    
Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
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MeSH Terms
Contrast Media / adverse effects*
Fibrosis / chemically induced
Gadolinium DTPA / adverse effects*
Magnetic Resonance Imaging*
Middle Aged
Renal Insufficiency, Chronic / complications*
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA

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