| Nephrogenic systemic fibrosis associated with gadolinium use. | |
| | |
MedLine Citation:
|
PMID: 18400614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Nephrogenic systemic fibrosis (NSF) is an idiopathic, progressive, systemic fibrosis that occurs in patients with renal diseases. Recently, gadolinium-containing contrast (Gd-contrast) has become a suspected causal factor for NFS. This report discusses two female patients with end-stage renal disease, aged 70 and 51 years, respectively, who developed histologically proven NSF after exposure to Gd-contrast. Clinically, both patients were characterized by fibrosis and induration of skin and muscle mainly in the limbs with joint contracture. In the first case, NSF developed gradually after undergoing evaluation by Gd-contrast magnetic resonance imaging (MRI) and subsequent surgery for her urothelial carcinoma. In the second patient, NSF developed after undergoing evaluation by Gd-contrast MRI for her right shoulder bursitis with calcification, and the conditions of NSF continued to worsen after the surgical treatment of this right shoulder lesion. Although the role of Gd-contrast in NSF is still not well known, the correlation in our cases strongly suggests that it should be used with cautioned in patients with end-stage renal disease. Both of our patients underwent surgery before or during the development of NSF, indicating that the surgical procedure may be a contributing factor. |
| | |
Authors:
|
Chi-Chao Chao; Chih-Chao Yang; Cheng-Hsiang Hsiao; Ming-Kai Pan; Chin-Hsuan Lin; Sung-Tsang Hsieh |
Related Documents
:
|
12142724 - Beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease. 8169874 - Idiopathic retroperitoneal fibrosis: a report of 3 cases. 18554694 - Cystic dysplasia of testis associated with ectopic ureter causing chronic orchalgia. 12296504 - The alcohol use disorders identification test (audit) predicts alcohol withdrawal sympt... 21214294 - The significance of a positive dat in thalassemia patients. 3125004 - Diarrhea associated with severe hypoalbuminemia: a comparison of a peptide-based chemic... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of the Formosan Medical Association = Taiwan yi zhi Volume: 107 ISSN: 0929-6646 ISO Abbreviation: J. Formos. Med. Assoc. Publication Date: 2008 Mar |
Date Detail:
|
Created Date: 2008-05-09 Completed Date: 2008-08-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9214933 Medline TA: J Formos Med Assoc Country: China (Republic : 1949- ) |
Other Details:
|
Languages: eng Pagination: 270-4 Citation Subset: IM |
Affiliation:
|
Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Contrast Media / adverse effects* Female Fibrosis / chemically induced Gadolinium DTPA / adverse effects* Humans Magnetic Resonance Imaging* Middle Aged Renal Insufficiency, Chronic / complications* |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Crossed pulmonary arteries: report of two cases with emphasis on three-dimensional helical computed ...
Next Document: Citric acid as a decalcifying agent for the excised calcified human heart valves.