| Nephritis and the risk of acute myocardial infarction in patients with systemic lupus erythematosus. | |
| | |
MedLine Citation:
|
PMID: 20483044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUNDS: Patients with systemic lupus erythematosus (SLE) have an increased risk of acute myocardial infarction (AMI). We examined if nephritis or other clinical manifestations of SLE identified patients at increased risk. METHODS: In this population-based case-control study, we identified patients with SLE hospitalized with an AMI in California in 1996-2000. We compared the frequency of six manifestations of SLE (nephritis, pleuritis, hemolytic anemia, thrombocytopenia, psychosis/major depression, seizures) and of venous thrombosis/pulmonary embolism, in this group (n=535) to the frequency of these manifestations in two control groups: patients with SLE hospitalised for pulmonary disease (n=529), and patients with SLE hospitalised for gastrointestinal bleeding (n=349). RESULTS: Nephritis was present in 23.7% of patients with AMI, 11.0% of patients with pulmonary disease and 25.2% of patients with gastrointestinal bleeding. In adjusted analyses, nephritis was more common in the AMI group (odds ratio (OR) 2.85, 95% confidence interval (CI) 1.97-4.14; p<.0001) than in the pulmonary disease control group. Among women, nephritis was more common in the AMI group (OR 2.83; 95% CI 1.33-6.01; p=0.007) than in the gastrointestinal bleeding control group. Psychosis/major depression was less common among patients with AMI. CONCLUSIONS: Among patients with SLE, nephritis was associated with 2.8-fold increased risk of AMI. |
| | |
Authors:
|
D K Wells; M M Ward |
Related Documents
:
|
1790634 - Clinical and serological spectrum of systemic lupus erythematosus in greek children. 8833894 - Antibody to c1-inhibitor in a patient receiving c1-inhibitor infusions for treatment of... 3237704 - Vascular lesions in lupus nephritis. 7211914 - Coronary arterial disease in systemic lupus erythematosus; quantification of degrees of... 22002594 - Parental consanguinity is associated with a severe phenotype in common variable immunod... 8193754 - Indirect laryngoscopic evaluation of vocal cord function in patients undergoing transhi... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Intramural Date: 2010-05-13 |
Journal Detail:
|
Title: Clinical and experimental rheumatology Volume: 28 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 2010 Mar-Apr |
Date Detail:
|
Created Date: 2010-05-20 Completed Date: 2010-08-23 Revised Date: 2011-07-25 |
Medline Journal Info:
|
Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: Italy |
Other Details:
|
Languages: eng Pagination: 223-9 Citation Subset: IM |
Affiliation:
|
Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Anemia, Hemolytic / epidemiology California / epidemiology Case-Control Studies Databases, Factual Depressive Disorder, Major / epidemiology Epilepsy / epidemiology Female Humans Lupus Nephritis / epidemiology* Male Middle Aged Myocardial Infarction / epidemiology* Pleurisy / epidemiology Risk Factors Thrombocytopenia / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
|
ZIA AR041153-05/AR/NIAMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Validity, responsiveness and feasibility of an Italian version of the Canadian Occupational Performa...
Next Document: Public healthcare attendance associates with enhanced conventional and non-conventional atherosclero...