| Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response. | |
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MedLine Citation:
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PMID: 15213266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of nephritis-associated antigen as a virulence factor for acute poststreptococcal glomerulonephritis (APSGN) remains to be fully clarified. Nephritis-associated plasmin receptor (NAPlr) was previously isolated from group A streptococcus (GAS) and shown to bind plasmin(ogen). The nucleotide sequence of the naplr gene from GAS isolates obtained from patients with APSGN was determined. The sequence of the putative open reading frame (1011 bp) showed 99.8% identity among isolated strains. Homology screen revealed an exact match with streptococcal glyceraldehyde-3-phosphate dehydrogenase (GAPDH). NAPlr exhibited GAPDH activity in zymography, and it activated the complement pathway in vitro. In APSGN kidney biopsy specimens, NAPlr was observed mainly in the early stage of the disease (1 to 14 d after onset) but was not colocalized with either C3 or IgG as assessed by double immunofluorescence staining. Sera of patients with APSGN, patients with GAS infection without renal involvement, nonrenal pediatric patients, and healthy adults as controls were assayed for anti-NAPlr antibody titers. Anti-NAPlr antibodies were present most frequently in APSGN sera, and antibody titers were also significantly higher than in patients with GAS infection alone or in other control patients. Moreover, antibody titers remained elevated during the entire 10-yr follow-up period. |
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Authors:
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Nobuyuki Yoshizawa; Kazuo Yamakami; Masayuki Fujino; Takashi Oda; Kikuko Tamura; Koichi Matsumoto; Tetsuzo Sugisaki; Michael D P Boyle |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Society of Nephrology : JASN Volume: 15 ISSN: 1046-6673 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-23 Completed Date: 2004-11-19 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 1785-93 Citation Subset: IM |
Affiliation:
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Department of Public Health, National Defense Medical College, Saitama, Japan. yoshizawa-npr@umin.ac.jp |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AB088214; AB088215; AB088216; AB088217; AF520813 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Amino Acid Sequence Base Sequence Biopsy Child Child, Preschool Complement Activation Complement C3 / metabolism Dose-Response Relationship, Drug Female Follow-Up Studies Glomerulonephritis / etiology*, immunology* Humans Immunoglobulin G / chemistry Kidney / metabolism, pathology Male Microscopy, Fluorescence Middle Aged Molecular Sequence Data Nephritis / pathology* Open Reading Frames Receptors, Peptide / biosynthesis* Sequence Analysis, DNA Streptococcal Infections / immunology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 0/Immunoglobulin G; 0/Receptors, Peptide; 0/plasmin receptor |
| Comments/Corrections | |
Comment In:
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J Am Soc Nephrol. 2004 Jul;15(7):1961-2
[PMID:
15213287
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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