Document Detail

Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response.
MedLine Citation:
PMID:  15213266     Owner:  NLM     Status:  MEDLINE    
The role of nephritis-associated antigen as a virulence factor for acute poststreptococcal glomerulonephritis (APSGN) remains to be fully clarified. Nephritis-associated plasmin receptor (NAPlr) was previously isolated from group A streptococcus (GAS) and shown to bind plasmin(ogen). The nucleotide sequence of the naplr gene from GAS isolates obtained from patients with APSGN was determined. The sequence of the putative open reading frame (1011 bp) showed 99.8% identity among isolated strains. Homology screen revealed an exact match with streptococcal glyceraldehyde-3-phosphate dehydrogenase (GAPDH). NAPlr exhibited GAPDH activity in zymography, and it activated the complement pathway in vitro. In APSGN kidney biopsy specimens, NAPlr was observed mainly in the early stage of the disease (1 to 14 d after onset) but was not colocalized with either C3 or IgG as assessed by double immunofluorescence staining. Sera of patients with APSGN, patients with GAS infection without renal involvement, nonrenal pediatric patients, and healthy adults as controls were assayed for anti-NAPlr antibody titers. Anti-NAPlr antibodies were present most frequently in APSGN sera, and antibody titers were also significantly higher than in patients with GAS infection alone or in other control patients. Moreover, antibody titers remained elevated during the entire 10-yr follow-up period.
Nobuyuki Yoshizawa; Kazuo Yamakami; Masayuki Fujino; Takashi Oda; Kikuko Tamura; Koichi Matsumoto; Tetsuzo Sugisaki; Michael D P Boyle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  15     ISSN:  1046-6673     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-23     Completed Date:  2004-11-19     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1785-93     Citation Subset:  IM    
Department of Public Health, National Defense Medical College, Saitama, Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AB088214;  AB088215;  AB088216;  AB088217;  AF520813
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MeSH Terms
Age Factors
Amino Acid Sequence
Base Sequence
Child, Preschool
Complement Activation
Complement C3 / metabolism
Dose-Response Relationship, Drug
Follow-Up Studies
Glomerulonephritis / etiology*,  immunology*
Immunoglobulin G / chemistry
Kidney / metabolism,  pathology
Microscopy, Fluorescence
Middle Aged
Molecular Sequence Data
Nephritis / pathology*
Open Reading Frames
Receptors, Peptide / biosynthesis*
Sequence Analysis, DNA
Streptococcal Infections / immunology*
Time Factors
Reg. No./Substance:
0/Complement C3; 0/Immunoglobulin G; 0/Receptors, Peptide; 0/plasmin receptor
Comment In:
J Am Soc Nephrol. 2004 Jul;15(7):1961-2   [PMID:  15213287 ]

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