Document Detail

Nephrectomy-induced alterations in the synthesis of catecholamines in the sympathetic nervous system and central nervous system.
MedLine Citation:
PMID:  2897199     Owner:  NLM     Status:  MEDLINE    
Reduction in renal function is a key factor to the development of salt-dependent hypertension; however, the mechanism is obscure. To examine the role of the sympathetic nervous system (SNS) and central catecholaminergic neurons in this predisposition to the development of hypertension, the activity of tyrosine hydroxylase (TH) was determined in SNS and in several brain regions. In another group of unilaterally nephrectomized rabbits, cardiovascular responsiveness to norepinephrine was determined. A unilateral nephrectomy increased the activity of TH in the midmedulla, a brain region important in the baroreflex regulation of blood pressure, and in the adrenal gland, the major source of circulating catecholamines. The activity of TH was decreased in the pons-upper medulla region. No alterations were found in the proximal and distal mesenteric arteries, lower medulla, midbrain or hypothalamus. No alteration in blood pressure or cardiovascular responsiveness to norepinephrine was found. This study indicates that a unilateral nephrectomy produces long-lasting effects on central catecholaminergic neurons and the sympathetic nervous system without an effect on blood pressure or cardiovascular responsiveness.
A L Rauch; W G Campbell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  1     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-07-12     Completed Date:  1988-07-12     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-3     Citation Subset:  IM    
Department of Pathology, Emory University, Atlanta, Georgia.
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MeSH Terms
Adrenal Glands / enzymology
Blood Pressure
Catecholamines / biosynthesis*
Central Nervous System / enzymology,  metabolism*
Hypertension / etiology
Medulla Oblongata / enzymology
Neurons / enzymology,  metabolism
Norepinephrine / biosynthesis
Sympathetic Nervous System / enzymology,  metabolism*
Tyrosine 3-Monooxygenase / analysis
Reg. No./Substance:
0/Catecholamines; 51-41-2/Norepinephrine; EC 3-Monooxygenase

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