Document Detail

Nepafenac-assisted mydriasis in a rabbit model.
MedLine Citation:
PMID:  20674259     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare the effectiveness of nepafenac 0.10% in achieving and maintaining pupil dilation with the effectiveness of flurbiprofen 0.03% and a placebo in a rabbit model.
SETTING: Department of Ophthalmology, University of California, San Francisco, California, USA.
DESIGN: Laboratory study.
METHODS: Adult pigmented rabbits were randomized to 3 equal-sized groups: placebo, flurbiprofen, and nepafenac. Cataract surgery was performed in randomized order by a surgeon who was masked to group assignment. The treatment or placebo was administered starting 1 day before surgery. Phenylephrine 10.0% was administered starting 30 minutes before surgery. Phacoemulsification was performed in standard fashion. Pupil measurements were recorded before and after surgery. A linear mixed model with a random effect for the rabbits and a fixed effect for the treatment groups was used to compare mean pupil diameters between groups.
RESULTS: Baseline pupil measurements were similar between the placebo, flurbiprofen, and nepafenac groups. Preoperative pupil dilation was statistically significantly greater in the nepafenac group (mean 11.5 mm ± 0.5 [SD]) than in the placebo group (mean 10.2 ± 1.1 mm) and the flurbiprofen group (mean 9.9 ± 1.1 mm) (P<.005 and P<.001, respectively). The greater dilation was maintained at the end of surgery, at which time the nepafenac group had statistically significantly larger pupils (mean 9.4 ± 1.2 mm) than the placebo group (mean 7.9 ± 0.6 mm) and the flurbiprofen group (mean 8.5 ± 0.9 mm) (P<.001 and P<.05, respectively).
CONCLUSION: Nepafenac was more effective than a placebo and flurbiprofen in achieving maximum preoperative and postoperative pupil mydriasis in rabbits.
Michael K Yoon; Ayman Naseri; Travis Porco; Stephen D McLeod
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-07-31
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  36     ISSN:  1873-4502     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2010-12-08     Revised Date:  2013-08-26    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1779-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
Department of Ophthalmology, University of California San Francisco, San Francisco, California, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Benzeneacetamides / administration & dosage*
Flurbiprofen / administration & dosage
Models, Animal
Mydriatics / administration & dosage*
Phenylacetates / administration & dosage*
Pupil / drug effects*
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Benzeneacetamides; 0/Mydriatics; 0/Phenylacetates; 0J9L7J6V8C/nepafenac; 5104-49-4/Flurbiprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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