Document Detail

Neovascularization by cardiomyoplasty.
MedLine Citation:
PMID:  9828284     Owner:  NLM     Status:  MEDLINE    
Nowadays cardiomyoplasty is used in cases of cardiac insufficiency as an alternative to cardiac transplant for patients with very developed ischemic cardiopathy, refractory to pharmacological treatment and without possibility of revascularization by using conventional techniques. OBJECTIVES: Our Cardiovascular Research Group has proposed as an objective, the detection of any possible myocardial neovascularization through the muscle used for cardiomyoplasty. In the case that there are new blood vessels to the diseased myocardium through the latissimus dorsi muscle flap in which it is wrapped and which aids it mechanically, it would be possible to confirm the working hypothesis that cardiomyoplasty not only improves the cardiocirculatory function mechanically but also facilitates a better blood flow to the ischemic myocardium. MATERIALS AND METHODS: The cardiomyoplasty technique is described using an experimental model of myocardial ischemia. The vascular cast is achieved by injecting methacrylate simultaneously into both the coronary tree and the wide dorsal muscle. In 15 experiments the connections between the coronary vascular system and the vascular structure of the latissimus dorsil muscle flap are demonstrated by several methods. CONCLUSIONS: We have demonstrated that cardiomyoplasty, as well as improving ventricular function, favours the revascularization of the myocardium. Cardiomyoplasty could be indicated for cases of ischemic cardiopathy in patients in whom it is not possible to perform direct revacularization using conventional methods.
J M Borrego; A Ordonez; A Hernandez; J Perez-Bernal; E Gutierrez; P Garcia-Tejero; M Prieto
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia     Volume:  4     ISSN:  1341-1098     ISO Abbreviation:  Ann Thorac Cardiovasc Surg     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-04     Completed Date:  1999-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9703158     Medline TA:  Ann Thorac Cardiovasc Surg     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  266-70     Citation Subset:  IM    
Division of Cardiovascular Surgery and Center for Cardiovascular Research, Hospital Universitario "Virgen del Rocio," Seville, Spain.
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MeSH Terms
Cardiomyopathy, Dilated / complications,  radiography,  surgery*
Coronary Angiography
Coronary Circulation
Disease Models, Animal
Myocardial Ischemia / complications,  radiography,  surgery*
Myocardial Revascularization / methods*
Neovascularization, Physiologic*

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