Document Detail

Neopterin retards loss of serotonin N-acetyltransferase activity from cultured chick pineal glands.
MedLine Citation:
PMID:  6736956     Owner:  NLM     Status:  MEDLINE    
D-Neopterin at 10 microM delayed start of the decline of serotonin N-acetyltransferase (NAT) activity from the peak level in the cycle exhibited by chick pineal glands cultured under standard conditions in the dark. A less marked retardation of decline of NAT activity was found with glands cultured under diurnal illumination or those exposed prematurely to light. There were no significant effects of neopterin on the increases of NAT activity or peak levels of activity developed. The pteridine also retarded loss of NAT activity from the peak level developed in the dark when the time of explanting into culture was later in the (solar) day, but not when it was earlier. Neopterin had no effect on the cycle in cyclic GMP content of cultured chick pineal glands.
S D Wainwright; L K Wainwright
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  43     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-08-08     Completed Date:  1984-08-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  371-4     Citation Subset:  IM    
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MeSH Terms
Acetyltransferases / metabolism*
Arylamine N-Acetyltransferase / metabolism*
Biopterin / analogs & derivatives,  pharmacology*
Cells, Cultured
Circadian Rhythm / drug effects*
Pineal Gland / drug effects,  enzymology*
Pteridines / pharmacology*
Reg. No./Substance:
0/Pteridines; 22150-76-1/Biopterin; 670-65-5/Neopterin; EC 2.3.1.-/Acetyltransferases; EC N-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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