| Neopterin levels and left ventricular dysfunction in patients with chronic stable angina pectoris. | |
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MedLine Citation:
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PMID: 19577753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Left ventricular ejection fraction (LVEF) is the strongest predictor of survival in patients with chronic stable angina (CSA). Inflammation plays a key role in the pathogenesis of atherosclerosis and an enhanced inflammatory status has a negative impact on patient outcome. It is not known whether a relationship exists between inflammation and LV function in patients with CSA. We therefore sought to investigate whether C reactive protein (CRP) and neopterin correlate with LV dysfunction in patients with CSA. METHODS: We assessed 181 patients with CSA who underwent diagnostic coronary angiography in our institution. High-sensitivity CRP and neopterin serum concentrations were measured immediately before angiography. RESULTS: Baseline neopterin levels - but not CRP - showed a significant inverse correlation with LVEF (r=-0.222; p=0.003 and r=-0.097; p=0.194, respectively). After adjustment for relevant confounders which included, among others, the extent and severity of coronary disease, neopterin was found to be independently associated with LVEF (B -2.36, CI 95% -4.560 to -0.176, p=0.034). Moreover, high neopterin levels were an independent predictor of LV dysfunction (LVEF <45%) (OR, 8.52, CI 95% 1.10-65.64; p=0.040). Receiver operating characteristic analysis for neopterin showed an area under the curve of 0.736 (CI 95% 0.59-0.87, p<0.009) for prediction of LV dysfunction. CONCLUSION: Increased serum neopterin concentrations inversely correlate with LVEF values and high neopterin levels are a predictor of LV dysfunction in patients with CSA, irrespective of the extent and severity of coronary artery disease. Neopterin may thus be clinically useful for patient risk stratification. |
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Authors:
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Rodrigo Est??vez-Loureiro; Alejandro Recio-Mayoral; Juan A Sieira-Rodr??guez-Moret; Ernesto Trallero-Aragu??s; Juan Carlos Kaski |
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Publication Detail:
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Type: Journal Article Date: 2009-05-04 |
Journal Detail:
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Title: Atherosclerosis Volume: 207 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-30 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 514-8 Citation Subset: IM |
Affiliation:
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Cardiovascular Biology Research Centre, Division of Cardiac and Vascular Sciences, St George's, University of London, London, UK. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / blood*, complications, physiopathology, radiography Biological Markers / blood C-Reactive Protein / analysis Chronic Disease Coronary Angiography Databases as Topic Female Humans Inflammation Mediators / blood* Linear Models Logistic Models Male Middle Aged Neopterin / blood* Odds Ratio Pilot Projects Predictive Value of Tests ROC Curve Risk Assessment Risk Factors Stroke Volume Up-Regulation Ventricular Dysfunction, Left / blood*, etiology, physiopathology, radiography Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Inflammation Mediators; 670-65-5/Neopterin; 9007-41-4/C-Reactive Protein |
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