Document Detail

Neopterin levels in alcohol-dependent patients.
MedLine Citation:
PMID:  8937585     Owner:  NLM     Status:  MEDLINE    
Chronic alcohol exposure appears to suppress cell-mediated immunity which may contribute to the high incidence of infections among alcohol-dependent patients. We measured serum neopterin, as a marker of macrophage function and T-lymphocyte activation, in 26 alcohol-dependent patients. The mean serum neopterin in these patients was significantly lower than the mean serum neopterin in matched controls. In those who abstained, the mean serum neopterin at 3 weeks rose and was no longer significantly different from controls. Our findings suggest that alcohol-dependent patients have suppressed macrophage function which may be reversible within 3 weeks of abstention.
M O'Hanlon; S Salter; D Scull; M Labib
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  33 ( Pt 6)     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-11     Completed Date:  1997-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  536-9     Citation Subset:  IM    
Department of Psychiatry, Priority Unit, Dudley, West Midlands, UK.
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MeSH Terms
Alanine Transaminase / blood
Alcoholism / blood*
Aspartate Aminotransferases / blood
Biopterin / analogs & derivatives*,  blood
Chromatography, High Pressure Liquid
Middle Aged
T-Lymphocytes / chemistry,  physiology
Reg. No./Substance:
22150-76-1/Biopterin; 670-65-5/Neopterin; EC Aminotransferases; EC Transaminase

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