| Neopterin as a predictor of total and cardiovascular mortality in individuals undergoing angiography in the Ludwigshafen Risk and Cardiovascular Health study. | |
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MedLine Citation:
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PMID: 19395439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Neopterin is produced upon activation of the cell-mediated immune response, and may be a novel risk marker for adverse outcomes resulting from coronary artery disease. METHODS: We measured neopterin in 1801 study participants with and 511 without angiographic coronary artery disease. Rates of death were determined after a median follow-up of 8.0 years. RESULTS: Estimated glomerular filtration rate and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were the strongest predictors of neopterin. Neopterin was positively related to age and inversely related to LDL cholesterol, HDL cholesterol, and triglycerides. Use of lipid-lowering drugs lowered neopterin. Sex, body mass index, diabetes mellitus, hypertension, smoking status, Friesinger coronary score, and clinical instability at presentation were not associated with neopterin. Unlike C-reactive protein, neopterin was not increased in unstable angina pectoris, non-ST-elevation myocardial infarction, or ST-elevation myocardial infarction. In the third and fourth quartiles of neopterin, unadjusted hazard ratios for death from any cause were 1.94 (95% CI 1.44-2.61) and 3.32 (95% CI 2.53-4.30) compared to individuals in the first quartile, whereas hazard ratios for death from cardiovascular causes were 2.14 (95% CI 1.44-3.18) and 3.84 (95% CI 2.67-5.52), respectively. Neopterin remained predictive of total and cardiovascular mortality after adjusting for sex, age, body mass index, type 2 diabetes, hypertension, smoking status, LDL cholesterol, HDL cholesterol, triglycerides, estimated glomerular filtration rate, NT-proBNP, and clinical status at presentation, but NT-proBNP substantially weakened this association. CONCLUSIONS: Neopterin is an independent predictor of all-cause and cardiovascular mortality in individuals with or without stable coronary artery disease. |
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Authors:
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Tanja B Grammer; Dietmar Fuchs; Bernhard O Boehm; Bernhard R Winkelmann; Winfried Maerz |
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Publication Detail:
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Type: Journal Article Date: 2009-04-24 |
Journal Detail:
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Title: Clinical chemistry Volume: 55 ISSN: 1530-8561 ISO Abbreviation: Clin. Chem. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-29 Completed Date: 2009-06-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421549 Medline TA: Clin Chem Country: United States |
Other Details:
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Languages: eng Pagination: 1135-46 Citation Subset: IM |
Affiliation:
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Synlab Centre of Laboratory Diagnostics Heidelberg, Heidelberg, Germany. tanja.grammer@ synlab.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Cardiovascular Diseases / blood, mortality* Coronary Angiography* Female Germany Glomerular Filtration Rate Humans Male Middle Aged Neopterin / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 670-65-5/Neopterin |
| Comments/Corrections | |
Comment In:
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Clin Chem. 2009 Jun;55(6):1056-7
[PMID:
19395434
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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