Document Detail

Neoplastic transformation of a human hybrid cell line by alpha particles in relation to mammography X rays.
MedLine Citation:
PMID:  17145730     Owner:  NLM     Status:  MEDLINE    
The hybrid cell line CGL1 is the only cell line which allows quantitation of neoplastic transformation in human cells. Hybrid cells were exposed to 3.4 MeV alpha particles or to mammography X rays (29 kV(p)) and both survival and neoplastic cell transformation were assayed. For comparison, previously published data obtained with 200 kV(p) X rays are also included. Alpha particles were significantly more efficient than 29 kV(p) X rays in cell killing. Surprisingly, the efficiency of mammography X rays for the induction of neoplastic cell transformation was close to that observed for alpha particles.
M Frankenberg-Schwager; S Spieren; E Pralle; D Frankenberg
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-04
Journal Detail:
Title:  Radiation protection dosimetry     Volume:  122     ISSN:  0144-8420     ISO Abbreviation:  Radiat Prot Dosimetry     Publication Date:  2006  
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109958     Medline TA:  Radiat Prot Dosimetry     Country:  England    
Other Details:
Languages:  eng     Pagination:  180-4     Citation Subset:  IM    
University of Goettingen, Center of Radiology, Department of Nuclear Medicine, Von-Siebold-Strasse 3, D-37075 Goettingen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alpha Particles*
Cell Line
Cell Survival / radiation effects*
Cell Transformation, Neoplastic / pathology*,  radiation effects*
Dose-Response Relationship, Radiation
Hela Cells
Hybridomas / pathology*,  radiation effects*
Radiation Dosage

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Genome-wide gene expression changes in normal human fibroblasts in response to low-LET gamma-radiati...
Next Document:  Alpha-hit, cellular dose, cell transformation and inactivation probability distributions of radon pr...